02078nas a2200397   4500000000100000008004100001260001200042653001900054653002600073653001200099653002600111653001900137100002100156700001300177700001300190700001200203700001600215700001600231700001500247700001300262700002000275700001700295700001400312700001100326700001300337700001500350700001700365700001500382700001500397245009200412856007100504300000800575490000700583520107600590022001401666       2023                            d  c01/202310aimmune markers10ainflammatory cytokine10aleprosy10aLeprosy complications10asoluble TREM-11 aBezerra-Santos M1 aBomfim L1 aSantos C1 aCunha M1 ade Moraes E1 aCazzaniga R1 aTenório M1 aAraujo J1 aMenezes-Silva L1 aMagalhães L1 aBarreto A1 aReed S1 aDuthie M1 aLipscomb M1 ade Almeida R1 ade Moura T1 ade Jesus A00asTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients.  uhttps://www.frontiersin.org/articles/10.3389/fmed.2023.1177375/pdf  a1-80 v103 a<p>Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment ( = 51) and from their household contacts (HHCs; = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels &gt;210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.</p>
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