02308nas a2200277   4500000000100000008004100001260001200042653000900054653000900063653000900072653001200081653003000093100002700123700001300150700001300163700001400176700001300190700001700203700001500220245011300235856006700348300000900415490000600424520158600430022001402016       2023                            d  c10/202310aTLR110aTLR210aTLR610aleprosy10asingle nucleotide variant1 aGutierrez-Castañeda L1 aAcosta C1 aBustos M1 aGarcía D1 aBohada D1 aRodríguez R1 aGuerrero M00aSingle Nucleotide Variants in the TLR1, TLR2 and TLR6 Genes: A Case-Control Study in a Colombian Population.  uhttps://www.mdpi.com/2414-6366/8/10/473/pdf?version=1697451851  a1-130 v83 a<p><strong>Background: </strong>Single nucleotide variants in toll-like receptor genes play a crucial role in leprosy susceptibility or resistance.</p>

<p><strong>Methods: </strong>With an epidemiology case-control study, associations between SNVs rs5743618 in TLR1, rs5743708 in TLR2, and rs5743810 in TLR6 and overall susceptibility for leprosy were estimated in 114 cases and 456 controls. Following that, stratified analysis was performed. DNA was extracted from peripheral blood. Genotyping was performed using predesigned TaqMan probes.</p>

<p><strong>Results: </strong>The A/G genotype of rs5743810 behaved as a protective factor for the development of leprosy in the codominant (OR= 0.37; 95% CI = 016-0.86, = 0.049) and over-dominant (OR = 0.38; 95% CI = 0.16-0.88, = 0.019) inheritance models. The A/G and A/A genotypes behaved as a protective factor (OR = 0.39; 95% CI = 0.17-0.87, = 0.016) in the dominant model. The SNVs rs5743618 and rs5743708 showed no association with any of the models. The CGG haplotype (rs5743618-rs5743708-rs5743810) behaved as a susceptibility factor for developing leprosy (OR = 1.86; 95% CI = 1.11-3.10, = 0.019). The latter haplotype behaved as a susceptibility factor for leprosy development in women (OR = 2.39; 95% CI = 1.21-4.82, = 0.013).</p>

<p><strong>Conclusions: </strong>The identified variants in the genes encoding TLRs, specifically rs5743810 in TLR6 and CGG (rs5743618-rs5743708-rs5743810) haplotypes, may somehow explain leprosy susceptibility in the studied population in a leprosy endemic region in Colombia.</p>
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