01290nas a2200181   4500000000100000008004100001260001200042100001000054700001700064700001300081700001500094245014400109856007100253300001000324490000700334520075300341022001401094       2023                            d  c11/20231 aXie C1 aStryjewska B1 aMcNiff J1 aShiferaw B00aErythema nodosum leprosum after allergen immunotherapy as initial presentation of lepromatous leprosy treated with novel multidrug regimen.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615896/pdf/main.pdf  a77-800 v413 a<p>Although &lt;5% of the world’s population is seemingly susceptible to Mycobacterium leprae infection, host genetics and environmental factors, including immunodeficient or immunosuppressed states, predispose toward the severe disease spectral state of the lepromatous (multibacillary) leprosy.1 We present a case of a patient undergoing allergen immunotherapy, who suddenly developed erythema nodosum leprosum (ENL) as the initial manifestation of lepromatous leprosy (LL) and was treated with a novel monthly multidrug antibiotic regimen in combination with immunomodulatory therapy. This is a rare case report of a difficult-to-treat leprosy immune reaction that developed after a preceding immunologic event of allergen immunotherapy.</p>
  a2352-5126