01194nas a2200181   4500000000100000008004100001260001200042653002000054653001900074100001400093700001300107245009300120856009600213300000800309490000700317520067400324022001400998       2023                            d  c01/202310aImmune Response10aInterleukin-171 aZaniolo L1 aDamazo A00aTh17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615336/pdf/1678-9849-rsbmt-56-e0265-2023.pdf  a1-50 v563 a<p>While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-1β and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.</p>
  a1678-9849