01717nas a2200229   4500000000100000008004100001260001200042653002300054653002500077653001500102653001200117653001600129653002300145100001200168700001300180700001300193700001200206700001200218245009000230520115300320022001401473       2023                            d  c11/202310aCell wall proteins10aMycobacterium leprae10aBiomarkers10aleprosy10aproteomics.10asecretory proteins1 aSingh S1 aSharma D1 aGautam S1 aArora M1 aBisht D00aExploring the Cell Wall and Secretory Proteins of Mycobacterium leprae as Biomarkers.3 a<p>The bacterial cell wall is composed of a wide variety of intricate proteins in addition to lipids, glycolipids, and polymers. Given the diversity of cell wall proteins among bacterial species, they are a feasible target for biomarker identification and characterization in clinical research and diagnosis of the disease. The slow growth rate of Mycobacterium leprae poses a major hurdle in the accurate diagnosis of leprosy before the onset of peripheral neuropathy. The use of biomarker- based diagnostic methods can help in preventing the spread and manifestation of leprosy. Despite many advances in research methods and techniques, there remains a knowledge gap regarding the cell wall proteomes of M. leprae that can be used as biomarkers. The cell wall and secretory proteins of M. leprae are the major focus of this review article. This article enfolds the characteristics and functions of M. leprae cell wall proteins and gives an insight into those cell wall proteins that are yet to be established as biomarkers. Tools and techniques used in cell wall extraction and biomarker identification can also be explored in this article.</p>
  a1875-5305