02065nas a2200397   4500000000100000008004100001260001200042653002100054653001900075653003400094653001200128653003200140653003700172653003200209653002500241653002000266653004700286100001200333700001500345700001200360700001400372700001400386700001300400700001200413700001400425700001200439700001100451700001300462700001500475245011300490856006000603300001200663490000700675520097100682022001401653       2023                            d  c09/202310adrug development10aDrug Discovery10aHuman African Trypanosomiasis10aMalaria10aNeglected Tropical Diseases10aProduct development partnerships10aPublic-private partnerships10aRepurposing know-how10aschistosomiasis10aSwiss Tropical and Public Health Institute1 aMeier L1 aAntillon M1 aBurri C1 aChitnis N1 aEndriss Y1 aKeiser J1 aMoore S1 aMüller P1 aPenny M1 aVoss T1 aMäser P1 aUtzinger J00aRepurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute.  uhttps://www.chimia.ch/chimia/article/view/2023_582/6292  a582-5920 v773 a<p>In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently utilising existing knowledge and resources. Repurposing know-how, a strategy that capitalises on previously acquired information and expertise, has emerged as a powerful approach to accelerate drug discovery and development processes, often at a fraction of the costs of de novo developments. For 80 years, collaborating within a network of partnerships, the Swiss Tropical and Public Health Institute (Swiss TPH) has been working along a value chain from innovation to validation and application to combat poverty-related diseases. This article presents an overview of selected know-how repurposing initiatives conducted at Swiss TPH with a particular emphasis on the exploration of drug development pathways in the context of neglected tropical diseases and other infectious diseases of poverty, such as schistosomiasis, malaria and human African trypanosomiasis.</p>
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