02179nas a2200229   4500000000100000008004100001260001200042653001800054653001200072653003300084100001200117700001100129700001300140700001400153700001300167245011900180856007800299300001200377490000700389520153900396022001401935       2023                            d  c01/202310aImmunotherapy10aleprosy10aMycobacterium indicus pranii1 aDogra S1 aJain S1 aSharma A1 aChhabra S1 aNarang T00a (MIP) Vaccine: Pharmacology, Indication, Dosing Schedules, Administration, and Side Effects in Clinical Practice.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10718117/pdf/IDOJ-14-753.pdf  a753-7610 v143 a<p>(MIP), previously called Mw vaccine, is a one-of-a-kind immunomodulatory vaccine. It was indigenously developed in India for use in leprosy. MIP is heat-killed which is a non-pathogenic atypical mycobacterium belonging to Class IV of Runyon classification. It shares epitopes with and , which forms the rationale behind its use in leprosy and tuberculosis. MIP activates both innate and acquired immunity. It induces a Th1 and Th17 immune response along with downregulation of Th2 pathway and activates macrophages and dendritic cells. MIP vaccine is safe with adverse effects such as local site erythema, swelling, and rarely fever and other systemic reactions. Apart from leprosy, MIP has been used in dermatological diseases such as warts and psoriasis. Clinical trials have evaluated the efficacy of MIP in a plenitude of non-dermatological conditions such as category II tuberculosis, Gram-negative sepsis, non-small cell lung cancer, human immunodeficiency virus (HIV), muscle-invasive bladder cancer, and very recently, coronavirus 2019 (COVID-19). and animal studies have also demonstrated its utility in leishmaniasis, melanoma, and as a vaccine for the prevention of pregnancy. The PubMed database was searched using ", MIP, " as the keyword in title. This comprehensive review provides useful information for healthcare professionals about immunotherapeutic potential of MIP vaccine, its composition, dosing schedule, administration, and side effects besides its efficacy in various indications other than leprosy.</p>
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