02531nas a2200241   4500000000100000008004100001260001200042653002300054653004300077653001200120653002700132100001400159700002000173700001200193700001200205700001300217700001400230245016500244300001200409490000700421520184700428022001402275       2023                            d  c01/202310aHousehold contacts10aIgM antiphenolic glycolipid-1 antibody10aleprosy10asingle-dose rifampicin1 aFantoni O1 aRusmawardiana R1 aYahya Y1 aBahar E1 aToruan T1 aPurwoko M00aComparison of antiphenolic glycolipid-1 antibody levels in seropositive contacts of leprosy after 2 years of single-dose rifampicin as postexposure prophylaxis.  a399-4060 v123 a<p><strong>Background: </strong>Leprosy is still a global problem, especially in developing countries, including Indonesia. Ineffective prevention of leprosy leads to active transmission of the disease. World Health Organization (WHO) recommend post-exposure prophylaxis (PEP) with single dose of rifampicin (SDR) for leprosy patients. Previous study showed protective effect of SDR against leprosy, especially for the first 2 years. Hence, the use of PEP and IgM anti PGL-1 examination are required to suspend the chain of leprosy transmission. This study evaluated the effectiveness of SDR administration by comparing IgM anti-PGL-1 antibody levels in seropositive household contacts before and after 2 years of SDR administration.</p>

<p><strong>Methods: </strong>Analytical observational laboratory study comparing IgM anti PGL-1 antibody levels before and after 2 years of SDR administration in leprosy contacts, with a prospective follow-up study design. We conducted this study from December 2022 to January 2023 at Dr. Mohammad Hoesin General Hospital Palembang. All seropositive household contacts of leprosy who had been administrated SDR 2 years ago were included, then PGL-1 antibody levels were examined.</p>

<p><strong>Results: </strong>The use of SDR showed significant improvement in leprosy contacts after 2 years (P=0.000). The median antibody level before SDR administration was 1,209.20 (615.81 - 4,353.60), which decrease to 146.03 (0 - 2,487.80) U/mL after 2 years. There was statistically significant relationship between history of BCG vaccination (P=0.003) and IgM PGL-1 antibody levels after 2 years of SDR administration.</p>

<p><strong>Conclusion: </strong>There is a significant decrease in IgM anti PGL-1 antibody levels among leprosy contacts after 2 years of SDR chemoprophylaxis administration.</p>
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