01776nas a2200253   4500000000100000008004100001260001200042653003000054653002300084653001500107653003000122653001700152653002200169100001500191700001300206700001100219700001300230245009600243856007100339300001000410490000700420520108100427022001401508       2023                            d  c12/202310ahost-pathogen interaction10aLeprosy neuropathy10atratamento10aPeripheral Nervous System10aSchwann cell10aSystematic review1 aBrügger L1 aSantos M1 aLara F1 aMietto B00aWhat happens when Schwann cells are exposed to Mycobacterium leprae  - A systematic review.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10776321/pdf/main.pdf  a11-160 v153 a<p><em>Mycobacterium leprae</em>, the pathogen that causes human leprosy, has a unique affinity for infecting and persisting inside Schwann cells, the principal glia of the peripheral nervous system. Several studies have focused on this intricate host-pathogen interaction as an attempt to advance the current knowledge of the mechanisms governing nerve destruction and disease progression. However, during the chronic course of leprosy neuropathy, Schwann cells can respond to and internalize both live and dead&nbsp;<em>M. leprae</em>&nbsp;and bacilli-derived antigens, and this may result in divergent cellular pathobiological responses. This may also distinctly contribute to tissue degeneration, failure to repair, inflammatory reactions, and nerve fibrosis, hallmarks of the disease. Therefore, the present study systematically searched for published studies on&nbsp;<em>M. leprae</em>-Schwann cell interaction&nbsp;<em>in vitro</em>&nbsp;to summarize the findings and provide a focused discussion of Schwann cell dynamics following challenge with leprosy bacilli.</p>
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