01778nas a2200265 4500000000100000008004100001260001200042653001200054653003500066653001300101653002700114100002500141700001800166700001900184700001900203700001300222700001700235700001400252245006200266856007100328300001100399490000700410520108100417022001401498 2023 d c01/202410aleprosy10aleprosy differential diagnosis10aSyphilis10aSyphilis Serodiagnosis1 aLondoño-Echeverri M1 aVargas-Cely F1 aGarcía-Luna J1 aRomero-Rosas N1 aGarcia L1 aValderrama N1 aSalazar J00aSyphilis and leprosy coinfection: A diagnostic conundrum. uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10765237/pdf/main.pdf a98-1010 v433 a
Leprosy and syphilis cases are on the rise in some communities. Leprosy or Hansen disease is a neglected disease, classified by the World Health Organization as multibacillary or paucibacillary. It displays a wide spectrum of clinical phenotypes primarily involving the skin and peripheral nerves, ranging from macular lesions to disabling and mutilating disease. Its etiological agents are Mycobacterium leprae and Mycobacterium lepromatosis, which are obligate intracellular acid-fast bacilli. On the other hand, syphilis is a multistage chronic infection characterized by a long latent period following the initial symptomatic stages.
An accurate diagnosis is essential, especially in tropical and subtropical contexts where multiple challenging and coexisting diagnosis should also be considered. Here, we describe the case of a woman with a chronic nodular dermatosis initially attributed to secondary syphilis but in whom a diagnosis of multibacillary leprosy coinfected with latent syphilis was established.
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