01725nas a2200241   4500000000100000008004100001653001200042653002200054653002000076653002400096100001500120700001900135700001900154700001800173700001500191700001200206245012100218856006900339300001000408490000700418520104400425022001401469       2024                            d10aleprosy10amultidrug therapy10abacterial index10amorphological index1 aRahmi A. M1 aListiawan M. Y1 aMurtiastutik D1 aHidayati A. N1 aErvianti E1 aUtomo B00aUnveiling the Past: Retrospective Exploration of Multidrug Therapy (MDT) Efficacy in Multibacillary Leprosy Patients  uhttps://migrationletters.com/index.php/ml/article/view/8649/5581  a51-580 v213 a<p><strong>Background: </strong>The bacterial index (BI) and morphological index (MI) values on slit skin smear (SSS) examination are supporting examinations that can be used to evaluate the treatment of multibacillary (MB) leprosy patients.</p>

<p><strong>Method:</strong> This study was a retrospective study, by measuring SSS examination before and after treatment, from January 2018-December 2020 patients' medical records at Tertiary Hospital, Surabaya, Indonesia. In this study, 49 MB patients with a positive SSS examination and had completed multidrug therapy (MDT).</p>

<p><strong>Results:</strong> After completing MDT, the BI score was 0 at 71.4% (p&lt;0.05) and the MI score was 0% at 100% (p&lt;0.05).</p>

<p><strong>Conclusion:</strong> MDT therapy was shown to have significant results, but there was still a positive BI value of 28.6% and an increase in BI of 2% in patients. The current 12-dose MDT-MB therapy is still an option for patients with MB leprosy, particularly in endemic areas such as Indonesia.</p>
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