01907nas a2200289   4500000000100000008004100001260001200042653001200054653003000066653001800096653002100114100001400135700001200149700001400161700001200175700001300187700001200200700001600212700001200228700001400240700001600254245013500270856006500405490000700470520112600477022001401603       2024                            d  c03/202410aPDGF-BB10aErythema Nodosum Leprosum10aInterleukin-710aLeprosy reaction1 aBandjar F1 aTabri F1 aMuchtar S1 aHatta M1 aDjawad K1 aIlyas F1 aMusafirah S1 aMassi M1 aBukhari A1 aZainuddin A00aAnalysis of interleukin 7 and platelet-derived growth factor-BB mRNA expression as potential markers in erythema nodosum leprosum.  uhttps://www.pagepress.org/journals/dr/article/view/9773/92050 v163 a<p>Erythema nodosum leprosum (ENL) is an immunological complication of leprosy characterized by acute inflammation of the skin, nerves, and other organs. Identifying laboratory parameters is important for early diagnosis of leprosy reactions. Various cytokine biomarkers have been examined and only a few studies have reported on angiogenesis in leprosy. This study aims to understand the pathomechanism of ENL by examining IL-7 and platelet-derived growth factor (PDGF)-BB mRNA expression that can be the development and consideration of new effective therapies to prevent reactions, recurrences, and defects in leprosy. The study used a cross-sectional analytic design. Sampling was done by peripheral blood from the patient and measuring mRNA expression with specific primers RT-PCR. The expression of mRNA IL-7 and PDGF-BB was significantly different between multibasilar patients without reaction and with ENL reaction, where there was an increased expression in ENL patients. This could be used as the development of potential biomarkers in ENL and development of new therapeutic intervention pathways in ENL.</p>
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