02334nas a2200325   4500000000100000008004100001260004000042653001600082653002300098653001700121653001200138653001800150653001700168100001500185700002500200700001500225700001600240700001700256700001300273700001300286700001600299700001200315700001300327700001800340245008000358856007500438300001000513520147100523022001401994       2024                            d  bKorean Society for Medical Mycology10aAspergillus10aAspergillus flavus10aItraconazole10aLeprosy10aOnychomycosis10aVeterinarian1 aHertanto A1 aYulianto Listiawan M1 aErvianti E1 aHidayati AN1 aIndranarum T1 aSuyoso S1 aAstari L1 aAnggraeni S1 aWidia Y1 aBahat AA1 aKurniasari FT00aOnychomycosis Caused by Aspergillus in aPatient with Leprosy: A Case Report  uhttps://e-jmi.org/archive/download?paper_id=135&dn_type=pdf&is_paper=y  a19-233 a<p>Aspergillus spp., one of the most common nondermatophyte molds (NDMs) that cause onychomycosis, are saprophytic fungi that can act as zoonotic agents and cause various health issues, including onychomycosis, in humans. Predisposing factors for onychomycosis include nail trauma, immunosuppression, and occupation. Nails in patients with leprosy are prone to change and develop onychomycosis due to unrecognized trauma to the nail area. Here, we report the case of a 25-year-old woman with 2-month history of white patches in fingernails and toenails, which were also brittle and damaged. She was a veterinarian who had frequent, direct interaction with animals, particularly dogs and cats. She denied trauma prior to the manifestation of symptoms and was undergoing leprosy treatment, including corticosteroids for leprosy reactions. Examination with potassium hydroxide revealed hyphae, and the nail culture revealed growth of fungal colonies with the characteristics of A. flavus. She received four cycles of itraconazole at 400 mg/day. Two of the three afflicted nails showed complete cure, whereas one nail showed mycologic cure. A. flavus is frequently found in animals, including dogs and cats and might have been a source of Aspergillus transmission, suggesting the patient's occupation and immunosuppression as risk factors for onychomycosis. Onychomycosis due to Aspergillus, particularly A. flavus, responds well to itraconazole pulse monotherapy.</p>
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