TY - JOUR KW - MDT KW - Bedaquiline KW - leprosy KW - Multidrug therapy KW - Repurposing AU - Khera H AU - Narang T AU - Sharma A AU - Malhotra S AU - Kumar V AU - Chhabra S AU - Khan A AU - Suri V AU - Dogra S AU - Shafiq N AB -

Leprosy remains a significant public health concern despite major strides in treatment and control efforts. The Global Leprosy Strategy 2021-2030 and the National Strategic Plan for Leprosy 2023-2027 majorly focus on facilitating action to reach the goal of zero leprosy. Exploration of new treatment regimens is emphasized as one of the verticals of the multipronged approach for reaching the aforementioned goals. This becomes particularly pertinent in the wake of growing evidence for resistance to the drugs currently being used in the management of leprosy. Repurposed molecules present a very good approach in this direction. The present review aims to explore the potential of bedaquiline, a drug used for multidrug-resistant tuberculosis, as a potential addition to the therapeutic armamentarium of leprosy. Through this narrative review, the authors attempt to look into the available proof of concept, clinical evidence, potential risks, and possible ways forward with bedaquiline in leprosy.

BT - International journal of dermatology C1 - https://www.ncbi.nlm.nih.gov/pubmed/39258824 DA - 09/2024 DO - 10.1111/ijd.17485 J2 - Int J Dermatol LA - ENG M3 - Article N2 -

Leprosy remains a significant public health concern despite major strides in treatment and control efforts. The Global Leprosy Strategy 2021-2030 and the National Strategic Plan for Leprosy 2023-2027 majorly focus on facilitating action to reach the goal of zero leprosy. Exploration of new treatment regimens is emphasized as one of the verticals of the multipronged approach for reaching the aforementioned goals. This becomes particularly pertinent in the wake of growing evidence for resistance to the drugs currently being used in the management of leprosy. Repurposed molecules present a very good approach in this direction. The present review aims to explore the potential of bedaquiline, a drug used for multidrug-resistant tuberculosis, as a potential addition to the therapeutic armamentarium of leprosy. Through this narrative review, the authors attempt to look into the available proof of concept, clinical evidence, potential risks, and possible ways forward with bedaquiline in leprosy.

PY - 2024 T2 - International journal of dermatology TI - Exploring the therapeutic and prophylactic potential of bedaquiline in leprosy. SN - 1365-4632 ER -