TY - JOUR
KW - Erythema Nodosum Leprosum
KW - Multi-drug therapy
KW - leprosy 
AU - Pramudita AW
AU - Kariosentono H
AU - Evanti AM
AU - Asaduddin AH
AB - <jats:p>A case of a 58-year-old woman with lepromatous leprosy and severe ENL reaction is reported. The patient has symptoms of pustules for 1 year and the nodules were getting worse in the last week, accompanied by fever, joint pain, nausea, and vomiting. Physical examination revealed madarosis, infiltrates of both ears, and multiple painful erythematous nodules on the extremities and trunk. Slit skin smear examination showed bacterial index +3 and morphological index of 15%. Histopathological examination revealed neutrophil infiltration and vasculitis in the upper dermis. The patient was diagnosed with lepromatous leprosy and severe ENL reaction. The patient received multidrug therapy and methylprednisolone (62.5 mg/day), which was gradually reduced. The ENL reaction is caused by the deposition of M. leprae antigens and antibodies in small blood vessels, resulting in vasculitis and the release of enzymes that damage tissues. ENL reactions are commonly found in multibacillary MH and occur before, during, and after treatment. This reaction is mediated by cytokines produced by T-helper-2 (Th2). ENL reactions can cause disability.</jats:p>
BT - Cermin Dunia Kedokteran
DO - 10.55175/cdk.v51i12.1116
IS - 12
LA - ENG
M3 - Case Report
N2 - <jats:p>A case of a 58-year-old woman with lepromatous leprosy and severe ENL reaction is reported. The patient has symptoms of pustules for 1 year and the nodules were getting worse in the last week, accompanied by fever, joint pain, nausea, and vomiting. Physical examination revealed madarosis, infiltrates of both ears, and multiple painful erythematous nodules on the extremities and trunk. Slit skin smear examination showed bacterial index +3 and morphological index of 15%. Histopathological examination revealed neutrophil infiltration and vasculitis in the upper dermis. The patient was diagnosed with lepromatous leprosy and severe ENL reaction. The patient received multidrug therapy and methylprednisolone (62.5 mg/day), which was gradually reduced. The ENL reaction is caused by the deposition of M. leprae antigens and antibodies in small blood vessels, resulting in vasculitis and the release of enzymes that damage tissues. ENL reactions are commonly found in multibacillary MH and occur before, during, and after treatment. This reaction is mediated by cytokines produced by T-helper-2 (Th2). ENL reactions can cause disability.</jats:p>
PB - PT Kalbe Farma Tbk.
PY - 2024
SP - 696
EP - 699
T2 - Cermin Dunia Kedokteran
TI - Severe Erythema Nodosum Leprosum in Lepromatous Leprosy Patient
TT - Case Report
UR - https://cdkjournal.com/index.php/cdk/article/view/1116/994
VL - 51
SN - 2503-2720, 0125-913X
ER -