TY - STAND
KW - leprosy
KW - neuropathy
KW - neuroimmunology
KW - social implications
KW - mycobacterium
KW - peripheral neuropathy
KW - autonomic neuropathy
KW - small fiber neuropathy
KW - ganglionitis
KW - lepra
AU - Pitton Rissardo J
AU - Byroju VV
AU - Fornari Caprara AL
AB - <jats:p>Leprosy is one of the neglected tropical diseases, and its elimination is a public health problem globally. This manuscript comprehensively explores the neurological manifestations of leprosy, offering clinical insights and implications for diagnosis, management, and understanding of the disease. Beginning with a review of historical context, etiology, and epidemiology, we delve into the pathophysiology of leprosy neuropathy, highlighting mechanisms of nerve damage and immune response. Peripheral nerve involvement, including sensory and motor deficits, nerve enlargement, and deformities, is discussed in detail, along with challenges in diagnosis and management. Psychological and social implications of neurological deficits in leprosy are addressed, emphasizing the importance of holistic care and support. Emerging neuroimaging and molecular diagnostics trends offer promising avenues for improved diagnosis and therapeutic interventions. Novel therapeutic strategies are identified to enhance treatment efficacy and prevent disability in leprosy neuropathy by targeting immunomodulatory pathways, antibacterial agents, and personalized medicine approaches.</jats:p>
DO - 10.20944/preprints202412.1022.v1
LA - ENG
M3 - Article
N2 - <jats:p>Leprosy is one of the neglected tropical diseases, and its elimination is a public health problem globally. This manuscript comprehensively explores the neurological manifestations of leprosy, offering clinical insights and implications for diagnosis, management, and understanding of the disease. Beginning with a review of historical context, etiology, and epidemiology, we delve into the pathophysiology of leprosy neuropathy, highlighting mechanisms of nerve damage and immune response. Peripheral nerve involvement, including sensory and motor deficits, nerve enlargement, and deformities, is discussed in detail, along with challenges in diagnosis and management. Psychological and social implications of neurological deficits in leprosy are addressed, emphasizing the importance of holistic care and support. Emerging neuroimaging and molecular diagnostics trends offer promising avenues for improved diagnosis and therapeutic interventions. Novel therapeutic strategies are identified to enhance treatment efficacy and prevent disability in leprosy neuropathy by targeting immunomodulatory pathways, antibacterial agents, and personalized medicine approaches.</jats:p>
PB - MDPI AG
PY - 2024
SP - 1
EP - 19
TI - Exploring The Neurological Manifestations of Leprosy: Clinical Insights and Implications
UR - https://www.researchgate.net/profile/Jamir-Pitton-Rissardo/publication/386997205_Exploring_The_Neurological_Manifestations_of_Leprosy_Clinical_Insights_and_Implications/links/67602f881da39f149578a8dc/Exploring-The-Neurological-Manifestations-of-Leprosy-Cl
ER -