Sarcoidosis is a multisystem disease of unknown aetiology characterized by epithelial cell granulomas without caseation in different organs. It involves mainly the mediastinal and peripheral lymph nodes, lungs, skin, eyes, liver and spleen. It acts as a great mimicker of various skin and systemic diseases. Diagnosis is challenging and mainly done by exclusion. Histopathology shows well-formed naked epithelioid cell granulomas and inclusion bodies. Corticosteroids are the mainstay of treatment. Herein we report a 60-year-old male, who presented with asymptomatic multiple erythematous well-defined plaques over face, trunk and upper limb clinically looking like lepromatous leprosy. He was earlier treated with anti-leprosy drugs (ALD) for 6 months as facilities for slit-skin smears and biopsy were not available at that time, following which he showed no improvement. There was no motor/ sensory deficit and skin smear for acid-fast bacilli (AFB) was negative. Skin biopsy was taken from a representative lesion. Histopathological findings were suggestive of sarcoidosis. He then started oral and topical corticosteroids along with PUVA therapy, following which he showed significant improvement. This report highlights the need to access to slit-skin smears and histopathology to confirm or rule out the diagnosis of leprosy.
BT - Indian Journal of Leprosy LA - ENG M3 - Case Report N2 -Sarcoidosis is a multisystem disease of unknown aetiology characterized by epithelial cell granulomas without caseation in different organs. It involves mainly the mediastinal and peripheral lymph nodes, lungs, skin, eyes, liver and spleen. It acts as a great mimicker of various skin and systemic diseases. Diagnosis is challenging and mainly done by exclusion. Histopathology shows well-formed naked epithelioid cell granulomas and inclusion bodies. Corticosteroids are the mainstay of treatment. Herein we report a 60-year-old male, who presented with asymptomatic multiple erythematous well-defined plaques over face, trunk and upper limb clinically looking like lepromatous leprosy. He was earlier treated with anti-leprosy drugs (ALD) for 6 months as facilities for slit-skin smears and biopsy were not available at that time, following which he showed no improvement. There was no motor/ sensory deficit and skin smear for acid-fast bacilli (AFB) was negative. Skin biopsy was taken from a representative lesion. Histopathological findings were suggestive of sarcoidosis. He then started oral and topical corticosteroids along with PUVA therapy, following which he showed significant improvement. This report highlights the need to access to slit-skin smears and histopathology to confirm or rule out the diagnosis of leprosy.
PY - 2024 SP - 343 EP - 347 T2 - Indian Journal of Leprosy TI - Cutaneous Sarcoidosis Treated as Leprosy- A Case Report UR - https://www.ijl.org.in/published-articles/28122024074520/11.pdf ER -