Intraoperative cyanosis is most commonly caused by hypoxaemia. The anaesthetist is required to perform a rapid series of diagnostic manoeuvres and take remedial action. Occasionally methaemoglobin, sulfhaemoglobin, or haemoglobin M, undetected preoperatively, is the cause of the cyanosis. We report a case of methaemoglobinaemia secondary to dapsone ingestion that was diagnosed intraoperatively. Dapsone, a sulfone, is used therapeutically to treat leprosy and dermatitis herpetiformis. The differential diagnosis of cyanosis, and the origin and fate of methaemoglobin are discussed. In addition the diagnostic steps and the laboratory investigations required to make the diagnosis are listed.
BT - Canadian journal of anaesthesia = Journal canadien d'anesthesie C1 - http://www.ncbi.nlm.nih.gov/pubmed/3829290?dopt=Abstract DA - 1987 Jan DO - 10.1007/BF03007692 IS - 1 J2 - Can J Anaesth LA - eng N2 -Intraoperative cyanosis is most commonly caused by hypoxaemia. The anaesthetist is required to perform a rapid series of diagnostic manoeuvres and take remedial action. Occasionally methaemoglobin, sulfhaemoglobin, or haemoglobin M, undetected preoperatively, is the cause of the cyanosis. We report a case of methaemoglobinaemia secondary to dapsone ingestion that was diagnosed intraoperatively. Dapsone, a sulfone, is used therapeutically to treat leprosy and dermatitis herpetiformis. The differential diagnosis of cyanosis, and the origin and fate of methaemoglobin are discussed. In addition the diagnostic steps and the laboratory investigations required to make the diagnosis are listed.
PY - 1987 SP - 79 EP - 82 T2 - Canadian journal of anaesthesia = Journal canadien d'anesthesie TI - Intraoperative cyanosis: a case of dapsone-induced methaemoglobinaemia. VL - 34 SN - 0832-610X ER -