TY - JOUR KW - Adolescent KW - Adult KW - Brazil KW - Child KW - Child, Preschool KW - Female KW - Genes, Recessive KW - Genetic Predisposition to Disease KW - Humans KW - Infant KW - Infant, Newborn KW - leprosy KW - Male KW - Meiosis KW - Middle Aged KW - Morbidity KW - Phenotype KW - Prevalence KW - Risk Factors AU - Feitosa M F AU - Borecki I AU - Krieger H AU - Beiguelman B AU - Rao D C AB -

Data on leprosy patients have been obtained from the Dispensary of Leprosy of Campinas, São Paulo, where records on practically all cases of leprosy in the Campinas area during the period 1960-70 are filed. The whole sample comprises 10,886 individuals, distributed among 1,568 families. Complex segregation analysis was utilized to determine the nature of the genetic factors that may operate on leprosy and its subtypes. The results suggest the presence of a recessive major gene controlling susceptibility to leprosy per se, with frequency of approximately .05, although there are deviations from the expected Mendelian segregation proportions. Possible etiologic heterogeneity was examined by considering two subtypes separately: for lepromatous leprosy and tuberculoid leprosy there are suggestions for a segregating major effect; however, Mendelian transmission could not be demonstrated in either case. Therefore, there is no evidence to suggest unique genetic determinants for leprosy subtypes.

BT - American journal of human genetics C1 - http://www.ncbi.nlm.nih.gov/pubmed/7726175?dopt=Abstract DA - 1995 May IS - 5 J2 - Am. J. Hum. Genet. LA - eng N2 -

Data on leprosy patients have been obtained from the Dispensary of Leprosy of Campinas, São Paulo, where records on practically all cases of leprosy in the Campinas area during the period 1960-70 are filed. The whole sample comprises 10,886 individuals, distributed among 1,568 families. Complex segregation analysis was utilized to determine the nature of the genetic factors that may operate on leprosy and its subtypes. The results suggest the presence of a recessive major gene controlling susceptibility to leprosy per se, with frequency of approximately .05, although there are deviations from the expected Mendelian segregation proportions. Possible etiologic heterogeneity was examined by considering two subtypes separately: for lepromatous leprosy and tuberculoid leprosy there are suggestions for a segregating major effect; however, Mendelian transmission could not be demonstrated in either case. Therefore, there is no evidence to suggest unique genetic determinants for leprosy subtypes.

PY - 1995 SP - 1179 EP - 85 T2 - American journal of human genetics TI - The genetic epidemiology of leprosy in a Brazilian population. VL - 56 SN - 0002-9297 ER -