TY - JOUR KW - Adolescent KW - Adult KW - Africa KW - Age Factors KW - Aged KW - Carcinoma, Hepatocellular KW - Child KW - Child, Preschool KW - Ethnic Groups KW - Female KW - Hepatitis B KW - Hepatitis B Antibodies KW - Hepatitis B Antigens KW - Hepatitis B virus KW - Hepatomegaly KW - Humans KW - Infant KW - Liver Neoplasms KW - Male KW - Middle Aged KW - Senegal KW - Alpha-Fetoproteins AU - Coursaget P AU - Maupas P AU - Goudeau A AU - Chiron J P AU - Drucker J AU - Denis F AU - Diop-Mar I AB -

Clinical observations of patients with primary hepatocellular carcinoma (PHC) at Le Dantec Hospital, Dakar, Senegal, were studied to determine a correlation with hepatitis B virus (HBV) infection. Of the 103 patients with PHC, 80 had an active HBV infection (HBsAg and/or anti-HBc); 23 showed signs of previous HBV infection (anti-HBs and anti-HBc). The two groups were similar in the detection of alpha-fetoprotein (approximately 60%) and in the major clinical findings: hepatomegaly, 76.25% and 86.96%, respectively; and ascites, 57.50% and 47.83%, respectively. Jaundice, however, was three times more frequent (P < 0.01) in the group of patients with signs of active HBV replication. Distribution of HBV markers as a function of age at onset of PHC revealed that the presence of HBsAg was primarily confined to the sera of the younger patients (< 50 yr old). When compared with leprosy patients and blood donors, the younger PHC patients differed in the frequency of detection of HBsAg and anti-HBs. The older people (> 50 yr old) in the three groups (PHC patients, leprosy patients, and blood donors) had identical HBV markers.

BT - Journal of the National Cancer Institute C1 - http://www.ncbi.nlm.nih.gov/pubmed/6158589?dopt=Abstract DA - 1980 Oct DO - 10.1093/jnci/65.4.687 IS - 4 J2 - J. Natl. Cancer Inst. LA - eng N2 -

Clinical observations of patients with primary hepatocellular carcinoma (PHC) at Le Dantec Hospital, Dakar, Senegal, were studied to determine a correlation with hepatitis B virus (HBV) infection. Of the 103 patients with PHC, 80 had an active HBV infection (HBsAg and/or anti-HBc); 23 showed signs of previous HBV infection (anti-HBs and anti-HBc). The two groups were similar in the detection of alpha-fetoprotein (approximately 60%) and in the major clinical findings: hepatomegaly, 76.25% and 86.96%, respectively; and ascites, 57.50% and 47.83%, respectively. Jaundice, however, was three times more frequent (P < 0.01) in the group of patients with signs of active HBV replication. Distribution of HBV markers as a function of age at onset of PHC revealed that the presence of HBsAg was primarily confined to the sera of the younger patients (< 50 yr old). When compared with leprosy patients and blood donors, the younger PHC patients differed in the frequency of detection of HBsAg and anti-HBs. The older people (> 50 yr old) in the three groups (PHC patients, leprosy patients, and blood donors) had identical HBV markers.

PY - 1980 SP - 687 EP - 90 T2 - Journal of the National Cancer Institute TI - Primary hepatocellular carcinoma in intertropical Africa: relationship between age and hepatitis B virus etiology. VL - 65 SN - 0027-8874 ER -