Clofazimine has been in clinical use for almost 40 years, but little is known of its mechanism of action. The primary indication for clofazimine is multibacillary leprosy, but it is useful in several infectious and noninfectious diseases, such as typical myocobacterial infections, rhinoscleroma, pyoderma gangrenosum, necrobiosis lipoidica, severe acne, pustular psoriasis, and discoid lupus erythematosus. Postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2. Clinical experience, possible mechanisms of action, and side effects of clofazimine are summarized.
BT - Journal of the American Academy of Dermatology C1 - http://www.ncbi.nlm.nih.gov/pubmed/7829710?dopt=Abstract DA - 1995 Feb DO - 10.1016/0190-9622(95)90134-5 IS - 2 Pt 1 J2 - J. Am. Acad. Dermatol. LA - eng N2 -Clofazimine has been in clinical use for almost 40 years, but little is known of its mechanism of action. The primary indication for clofazimine is multibacillary leprosy, but it is useful in several infectious and noninfectious diseases, such as typical myocobacterial infections, rhinoscleroma, pyoderma gangrenosum, necrobiosis lipoidica, severe acne, pustular psoriasis, and discoid lupus erythematosus. Postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2. Clinical experience, possible mechanisms of action, and side effects of clofazimine are summarized.
PY - 1995 SP - 241 EP - 7 T2 - Journal of the American Academy of Dermatology TI - Clofazimine: a review of its medical uses and mechanisms of action. VL - 32 SN - 0190-9622 ER -