TY - JOUR
KW - Adult
KW - Aged
KW - Drug Administration Schedule
KW - Drug Therapy, Combination
KW - Emigration and Immigration
KW - Ethnic Groups
KW - Female
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Leprosy, Borderline
KW - Leprosy, lepromatous
KW - Leprosy, Tuberculoid
KW - Male
KW - Middle Aged
KW - Netherlands
KW - Retrospective Studies
AU - Post E
AU - Chin-a-Lien R A
AU - Bouman C
AU - Naafs B
AU - Faber W R
AB - <p><b>OBJECTIVE: </b>To inventory the changes in leprosy epidemiology in the Netherlands.</p><p><b>DESIGN: </b>Retrospective.</p><p><b>SETTING: </b>Academic Medical Centre (Amsterdam) and University Hospital Dijkzigt (Rotterdam), the Netherlands.</p><p><b>METHOD: </b>The medical records of all new leprosy patients in the period 1970-1991 were analysed.</p><p><b>RESULTS: </b>Between 1970 and 1991, 622 new leprosy patients were registered; 371 men (59.6%) and 251 women (40.4%). Most patients came from Surinam (73.3%) and Indonesia (7.2%). The mean time lapse between onset and treatment in the Netherlands was 10.1 years. Switching from monotherapy to combination therapy (1979) had no effect on the incidence of reversal reactions (cellular hypersensitivity in immunologically unstable patients), but did affect the incidence of erythema nodosum leprosum during the treatment.</p><p><b>CONCLUSION: </b>Leprosy in the Netherlands is an important disease, mainly from Surinam. The main advantage of combination therapy is the shortened duration of treatment. The treatment of choice is the one recommended by the WHO, the combination therapy with rifampicin administration once a month, because of the few adverse effects.</p>
BT - Nederlands tijdschrift voor geneeskunde
C1 - http://www.ncbi.nlm.nih.gov/pubmed/7935946?dopt=Abstract
CN - POST 1994
DA - 1994 Sep 24
IS - 39
J2 - Ned Tijdschr Geneeskd
LA - dut
N2 - <p><b>OBJECTIVE: </b>To inventory the changes in leprosy epidemiology in the Netherlands.</p><p><b>DESIGN: </b>Retrospective.</p><p><b>SETTING: </b>Academic Medical Centre (Amsterdam) and University Hospital Dijkzigt (Rotterdam), the Netherlands.</p><p><b>METHOD: </b>The medical records of all new leprosy patients in the period 1970-1991 were analysed.</p><p><b>RESULTS: </b>Between 1970 and 1991, 622 new leprosy patients were registered; 371 men (59.6%) and 251 women (40.4%). Most patients came from Surinam (73.3%) and Indonesia (7.2%). The mean time lapse between onset and treatment in the Netherlands was 10.1 years. Switching from monotherapy to combination therapy (1979) had no effect on the incidence of reversal reactions (cellular hypersensitivity in immunologically unstable patients), but did affect the incidence of erythema nodosum leprosum during the treatment.</p><p><b>CONCLUSION: </b>Leprosy in the Netherlands is an important disease, mainly from Surinam. The main advantage of combination therapy is the shortened duration of treatment. The treatment of choice is the one recommended by the WHO, the combination therapy with rifampicin administration once a month, because of the few adverse effects.</p>
PY - 1994
SP - 1960
EP - 3
T2 - Nederlands tijdschrift voor geneeskunde
TI - [Leprosy in The Netherlands in the period 1970-1991].
TT - Lepra in Nederland in de periode 1970-1991
UR - http://www.ntvg.nl/system/files/publications/1994119600001a.pdf
VL - 138
SN - 0028-2162
ER -