Mycobacterial infections represent major problems to global health care. Tuberculosis is feared particularly because of its high mortality rates whereas in leprosy the occurrence of immunopathology, particularly nerve damage, is a major problem since the bacillus itself is relatively harmless. Thus, both effective vaccination strategies as well as novel immunomodulating regimens are warranted for the control of morbidity and mortality in mycobacterial diseases. Since CD4+ Th1 cells and type-1 cytokines play a key role both in protective immunity and immunopathology in mycobacterial infections, we here describe new pharmacological and cytokine-based strategies to regulate Th1 immunity.
BT - International archives of allergy and immunology C1 - http://www.ncbi.nlm.nih.gov/pubmed/9250585?dopt=Abstract DA - 1997 Aug DO - 10.1159/000237615 IS - 4 J2 - Int. Arch. Allergy Immunol. LA - eng N2 -Mycobacterial infections represent major problems to global health care. Tuberculosis is feared particularly because of its high mortality rates whereas in leprosy the occurrence of immunopathology, particularly nerve damage, is a major problem since the bacillus itself is relatively harmless. Thus, both effective vaccination strategies as well as novel immunomodulating regimens are warranted for the control of morbidity and mortality in mycobacterial diseases. Since CD4+ Th1 cells and type-1 cytokines play a key role both in protective immunity and immunopathology in mycobacterial infections, we here describe new pharmacological and cytokine-based strategies to regulate Th1 immunity.
PY - 1997 SP - 400 EP - 8 T2 - International archives of allergy and immunology TI - Modulation of protective and pathological immunity in mycobacterial infections. VL - 113 SN - 1018-2438 ER -