TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Antibodies, Bacterial
KW - Data Interpretation, Statistical
KW - Erythema Nodosum
KW - Female
KW - Humans
KW - Immunoglobulin G
KW - Immunoglobulin M
KW - Interferon-gamma
KW - Leprostatic Agents
KW - Leprosy, Borderline
KW - Leprosy, lepromatous
KW - Leprosy, Tuberculoid
KW - Male
KW - Middle Aged
KW - Mycobacterium leprae
KW - Thalidomide
KW - Tumor Necrosis Factor-alpha
AU - Partida-Sanchez S
AU - Favila-Castillo L
AU - Pedraza-Sanchez S
AU - Gomez-Melgar M
AU - Saúl A
AU - Estrada-Parra S
AU - Estrada-Garcia I
AB - <p>A group of 9 Mexican lepromatous leprosy patients was studied at the beginning of a type II reaction (erythema nodosum leprosum, ENL) and after 1 or 2 months of thalidomide treatment. ENL patients at the onset of the reaction had slightly higher amounts of anti-Mycobacterium leprae IgG1 and IgG2 antibodies, compared to similar lepromatous patients that did not develop ENL. Neither these antibody levels nor IgM and the other IgG subclasses were importantly modified after thalidomide treatment. Serum TNF was significantly higher in the patients that developed ENL compared to those that did not develop the reaction. TNF levels were slightly decreased after 1 month of thalidomide treatment and significantly decreased after 2 months of treatment. Serum IFN-gamma was significantly lower in patients at the onset of ENL and was increased after 1 and 2 months of thalidomide treatment.</p>
BT - International archives of allergy and immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/9623511?dopt=Abstract
DA - 1998 May
DO - 10.1159/000023926
IS - 1
J2 - Int. Arch. Allergy Immunol.
LA - eng
N2 - <p>A group of 9 Mexican lepromatous leprosy patients was studied at the beginning of a type II reaction (erythema nodosum leprosum, ENL) and after 1 or 2 months of thalidomide treatment. ENL patients at the onset of the reaction had slightly higher amounts of anti-Mycobacterium leprae IgG1 and IgG2 antibodies, compared to similar lepromatous patients that did not develop ENL. Neither these antibody levels nor IgM and the other IgG subclasses were importantly modified after thalidomide treatment. Serum TNF was significantly higher in the patients that developed ENL compared to those that did not develop the reaction. TNF levels were slightly decreased after 1 month of thalidomide treatment and significantly decreased after 2 months of treatment. Serum IFN-gamma was significantly lower in patients at the onset of ENL and was increased after 1 and 2 months of thalidomide treatment.</p>
PY - 1998
SP - 60
EP - 6
T2 - International archives of allergy and immunology
TI - IgG antibody subclasses, tumor necrosis factor and IFN-gamma levels in patients with type II lepra reaction on thalidomide treatment.
UR - http://academia.edu/2039784/lgG_subclasses_antibodies_TNF_IFN-gamma_levels_in_patients_with_type-II_lepra_reaction_under_thalidomide_treatment
VL - 116
SN - 1018-2438
ER -