TY - JOUR
KW - Biopsy
KW - diagnosis
KW - Disease
KW - Epidemiology
KW - Immersion
KW - leprosy
KW - Light
KW - Macrophages
KW - Medicine
KW - Microscopy
KW - Mucous Membrane
KW - Nepal
KW - Neurology
KW - Paper
KW - Patients
KW - Peripheral nerves
KW - Schwann Cells
KW - Skin
KW - Time
KW - Transmission
AU - Pedley J C
AU - Harman D J
AU - Wauday H
AU - McDougall A C
AB - From a series of 342 nerve biopsies taken by one clinician over a period of 12 years in Nepal, this paper describes the histopathological findings in 153 biopsies from 119 patients suffering from tuberculoid, borderline (dimorphous) or lepromatous leprosy, who were untreated at the time of first presentation and diagnosis. They were taken during the course of other studies, mainly concerned with the mode of transmission of leprosy, and which included biopsies of skin, dartos muscle, nasal mucous membrane and nipple, results of which have already been published. Examination of serial sections by light microscopy revealed a density of cellular infiltration in non-lepromatous cases, or of bacilli in macrophages and Schwann cells in lepromatous cases, which was marked in degree and usually widespread from one end of the biopsy to the other. Intraneural caseation was recorded in four patients with tuberculoid or borderline-tuberculoid leprosy, and many others in this part of the spectrum showed extensive disruption of perineurial and endoneurial structure. In lepromatous patients, the numbers of bacilli in the endoneurial area not infrequently exceeded one thousand per oil immersion field. Although well known to histopathologists familiar with this disease, it is considered that the significance of these findings, in patients presenting for the first time, is not well appreciated by those working in general medicine, neurology, epidemiology, or even in leprosy control
BT - Journal of Neurology Neurosurgery and Psychiatry
DA - 1980///
IS - 3
LA - eng
N1 - Cited By (since 1996): 8 Export Date: 17 April 2007 Source: Scopus
N2 - From a series of 342 nerve biopsies taken by one clinician over a period of 12 years in Nepal, this paper describes the histopathological findings in 153 biopsies from 119 patients suffering from tuberculoid, borderline (dimorphous) or lepromatous leprosy, who were untreated at the time of first presentation and diagnosis. They were taken during the course of other studies, mainly concerned with the mode of transmission of leprosy, and which included biopsies of skin, dartos muscle, nasal mucous membrane and nipple, results of which have already been published. Examination of serial sections by light microscopy revealed a density of cellular infiltration in non-lepromatous cases, or of bacilli in macrophages and Schwann cells in lepromatous cases, which was marked in degree and usually widespread from one end of the biopsy to the other. Intraneural caseation was recorded in four patients with tuberculoid or borderline-tuberculoid leprosy, and many others in this part of the spectrum showed extensive disruption of perineurial and endoneurial structure. In lepromatous patients, the numbers of bacilli in the endoneurial area not infrequently exceeded one thousand per oil immersion field. Although well known to histopathologists familiar with this disease, it is considered that the significance of these findings, in patients presenting for the first time, is not well appreciated by those working in general medicine, neurology, epidemiology, or even in leprosy control
PY - 1980
SP - 198 
EP -  204
T2 - Journal of Neurology Neurosurgery and Psychiatry
TI - Leprosy in peripheral nerves: Histopathological findings in 119 untreated patients in Nepal
UR - http://www.scopus.com/scopus/inward/record.url?eid=2-s2.0-0018840372&partnerID=40&rel=R6.0.0
VL - 43
ER -