TY - JOUR
KW - Anti-Bacterial Agents
KW - Bacteriological Techniques
KW - DNA gyrase
KW - DNA Topoisomerase IV
KW - Drug Resistance, Bacterial
KW - Microbial Sensitivity Tests
KW - Mutation
KW - Mycobacterium leprae
KW - Mycobacterium tuberculosis
KW - Quinolones
KW - Topoisomerase II Inhibitors
AU - Kim H
AU - Suzuki H
AU - Matsuoka M
AU - Matsuba T
AU - Yokoyama K
AU - Nakajima C
AU - Suzuki Y
AB - <p>Drugs included in new-quinolone are used for the treatment of leprosy with single lesion. These drugs are also known to be effective drugs for the treatment of multi-drug resistant M. tuberculosis. Recent emergence of new-quinolone resistant M. leprae and M. tuberculosis enforced the urgent elucidation of the mode of emergence of new-quinolone resistant strains. In this review, new-quinolone drugs, their mode of action and mechanism of acquisition of resistance by M. leprae and M. tuberculosis were explained. And rapid differentiation methods for resistant bacilli were also introduced.</p>
BT - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/21404592?dopt=Abstract
DA - 2011 Feb
IS - 1
J2 - Nihon Hansenbyo Gakkai Zasshi
LA - jpn
N2 - <p>Drugs included in new-quinolone are used for the treatment of leprosy with single lesion. These drugs are also known to be effective drugs for the treatment of multi-drug resistant M. tuberculosis. Recent emergence of new-quinolone resistant M. leprae and M. tuberculosis enforced the urgent elucidation of the mode of emergence of new-quinolone resistant strains. In this review, new-quinolone drugs, their mode of action and mechanism of acquisition of resistance by M. leprae and M. tuberculosis were explained. And rapid differentiation methods for resistant bacilli were also introduced.</p>
PY - 2011
SP - 17
EP - 27
T2 - Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
TI - [Molecular mechanism of the acquisition of new-quinolone resistance in Mycobacterium leprae and M. tuberculosis and rapid differentiation methods for resistant bacilli].
VL - 80
SN - 1342-3681
ER -