TY - JOUR KW - Social stigma KW - Mycobacterium leprae KW - leprosy KW - Disability KW - diagnosis AU - Suzuki K AU - Akama T AU - Kawashima A AU - Yoshihara A AU - Yotsu R AU - Ishii N AB - Leprosy has affected humans for millennia and remains an important health problem worldwide, as evidenced by nearly 250 000 new cases detected every year. It is a chronic infectious disorder, caused by Mycobacterium leprae, that primarily affects the skin and peripheral nerves. Recent advances in basic science have improved our knowledge of the disease. Variation in the cellular immune response is the basis of a range of clinical manifestations. The introduction of multidrug therapy has significantly contributed to a decrease in the prevalence of the disease. However, leprosy control activities, including monitoring and prevention programs, must be maintained. BT - The Journal of Dermatology DA - 02/2012 DO - 10.1111/j.1346-8138.2011.01370.x IS - 2 J2 - J. Dermatol. LA - eng M1 - 2 N2 - Leprosy has affected humans for millennia and remains an important health problem worldwide, as evidenced by nearly 250 000 new cases detected every year. It is a chronic infectious disorder, caused by Mycobacterium leprae, that primarily affects the skin and peripheral nerves. Recent advances in basic science have improved our knowledge of the disease. Variation in the cellular immune response is the basis of a range of clinical manifestations. The introduction of multidrug therapy has significantly contributed to a decrease in the prevalence of the disease. However, leprosy control activities, including monitoring and prevention programs, must be maintained. PB - Blackwell Publishing Ltd PY - 2012 EP - 121–129 T2 - The Journal of Dermatology TI - Current status of leprosy: Epidemiology, basic science and clinical perspectives VL - 39 SN - 1346-8138 ER -