TY - JOUR KW - leprosy KW - History of leprosy KW - DNA AU - Gibbons A AB - The newly unveiled genome of a medieval strain of the mycobacterium that causes leprosy is a technical triumph borne of next-generation sequencing machines and clever new techniques to extract target DNA from a soup of ancient molecules. Awash in data, several labs are racing neck-and-neck to cull DNA from a Most Wanted list of other legendary killers: tuberculosis, plague, cholera, Leishmania, the potato blight, and AIDS. They gather traces of these culprits from ancient teeth, bones, hair, feces, and—in the case of potato blight—from skin and leaves, then unleash the sequencers. The work adds a new dimension to our understanding of historical events, revealing the true nature of the villains responsible for humanity's worst epidemics. BT - Science Magazine C1 - http://www.ncbi.nlm.nih.gov/pubmed/23766308 CN - GIBBONS2013 DO - 10.1126/science.340.6138.1278 IS - 6138 LA - eng N2 - The newly unveiled genome of a medieval strain of the mycobacterium that causes leprosy is a technical triumph borne of next-generation sequencing machines and clever new techniques to extract target DNA from a soup of ancient molecules. Awash in data, several labs are racing neck-and-neck to cull DNA from a Most Wanted list of other legendary killers: tuberculosis, plague, cholera, Leishmania, the potato blight, and AIDS. They gather traces of these culprits from ancient teeth, bones, hair, feces, and—in the case of potato blight—from skin and leaves, then unleash the sequencers. The work adds a new dimension to our understanding of historical events, revealing the true nature of the villains responsible for humanity's worst epidemics. PY - 2013 SP - 1278 EP - 1282 T2 - Science Magazine TI - On the trail of ancient killers VL - 340 ER -