Leprosy is a chronic granulomatous disease caused by the bacillus Mycobacterium leprae. It primarily affects the skin and peripheral nerves and is still endemic in various regions of the world. Clinical presentation depends on the patient's immune status at the time of infection and during the course of the disease. Leprosy is associated with disability and marginalization. Diagnosis is clinical and is made when the patient has at least 1 of the following cardinal signs specified by the World Health Organization: hypopigmented or erythematous macules with sensory loss; thickened peripheral nerves; or positive acid-fast skin smear or skin biopsy with loss of adnexa at affected sites. Leprosy is treated with a multidrug combination of rifampicin, clofazimine, and dapsone. Two main regimens are used depending on whether the patient has paucibacillary or multibacillary disease.
BT - Actas dermo-sifiliograficas C1 - http://www.ncbi.nlm.nih.gov/pubmed/23870850?dopt=Abstract CN - EICHELMANN 2013 english, EIGHELMANN 2013 spanish DA - 2013 Sep DO - 10.1016/j.adengl.2012.03.028 IS - 7 J2 - Actas Dermosifiliogr LA - eng N1 -Free full text available: - in Spanish: http://www.elsevier.es/sites/default/files/elsevier/eop/S0001-7310(12)00154-8.pdf - in English: http://www.elsevier.es/sites/default/files/elsevier/eop/S1578-2190(13)00143-1.pdf
N2 -Leprosy is a chronic granulomatous disease caused by the bacillus Mycobacterium leprae. It primarily affects the skin and peripheral nerves and is still endemic in various regions of the world. Clinical presentation depends on the patient's immune status at the time of infection and during the course of the disease. Leprosy is associated with disability and marginalization. Diagnosis is clinical and is made when the patient has at least 1 of the following cardinal signs specified by the World Health Organization: hypopigmented or erythematous macules with sensory loss; thickened peripheral nerves; or positive acid-fast skin smear or skin biopsy with loss of adnexa at affected sites. Leprosy is treated with a multidrug combination of rifampicin, clofazimine, and dapsone. Two main regimens are used depending on whether the patient has paucibacillary or multibacillary disease.
PY - 2013 SP - 554 EP - 63 T2 - Actas dermo-sifiliograficas TI - Leprosy. An update: definition, pathogenesis, classification, diagnosis, and treatment. TT - Lepra: Puesta al día. definición, patogénesis, clasificación, diagnóstico y tratamiento UR - http://www.actasdermo.org/en/linkresolver/leprosy-an-update-definition-pathogenesis/S1578-2190(13)00143-1/?pubmed=true VL - 104 SN - 1578-2190 ER -