TY - JOUR
KW - Animals
KW - Anti-Infective Agents
KW - Antitubercular Agents
KW - Clarithromycin
KW - Clofazimine
KW - Colony Count, Microbial
KW - Dapsone
KW - Drug Resistance, Microbial
KW - Drug Resistance, Multiple
KW - Fluoroquinolones
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Nude
KW - Middle Aged
KW - Mycobacterium leprae
KW - Ofloxacin
KW - Rifampin
AU - Matsuoka M
AU - Kashiwabara Y
AU - Namisato M
AB - <p>Mycobacterium leprae were isolated from a Japanese patient, and susceptibility to antileprosy drugs was examined by the mouse foot pad method. The isolate was susceptible to clofazimine and clarithromycin, and resistant to dapsone, rifampin, ofloxacin and sparfloxacin. Mutations were identified in the genes associated with resistance to these drugs. The risk of the emergence of leprosy with multidrug resistance is emphasized.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/11332288?dopt=Abstract
DA - 2000 Dec
IS - 4
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>Mycobacterium leprae were isolated from a Japanese patient, and susceptibility to antileprosy drugs was examined by the mouse foot pad method. The isolate was susceptible to clofazimine and clarithromycin, and resistant to dapsone, rifampin, ofloxacin and sparfloxacin. Mutations were identified in the genes associated with resistance to these drugs. The risk of the emergence of leprosy with multidrug resistance is emphasized.</p>
PY - 2000
SP - 452
EP - 5
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - A Mycobacterium leprae isolate resistant to dapsone, rifampin, ofloxacin and sparfloxacin.
UR - http://ila.ilsl.br/pdfs/v68n4a07.pdf
VL - 68
SN - 0148-916X
ER -