In the current scenario of leprosy elimination, lepra reactions (LRs) remain a major persistent problem. Type 1 LR (T1LR) and type 2 LR (T2LR) are the major causes of nerve damage and permanent disabilities. The immunopathogenesis of LR have recently become an important field of research, since it may provide the relevant targets for the early detection and control of these episodes. Presently, there are no uniformly acceptable laboratory markers for LR. Genetic and serum markers in human host may predict susceptibility to reactions as well as progression of nerve damage in leprosy. Therefore, a deeper understanding of the molecular mechanisms involved in LR may provide a rational strategy for early diagnosis and prevention of the catastrophic consequences of LR.
BT - Indian journal of dermatology, venereology and leprology C1 - http://www.ncbi.nlm.nih.gov/pubmed/24177605?dopt=Abstract DA - 2013 Nov-Dec DO - 10.4103/0378-6323.120719 IS - 6 J2 - Indian J Dermatol Venereol Leprol LA - eng N2 -In the current scenario of leprosy elimination, lepra reactions (LRs) remain a major persistent problem. Type 1 LR (T1LR) and type 2 LR (T2LR) are the major causes of nerve damage and permanent disabilities. The immunopathogenesis of LR have recently become an important field of research, since it may provide the relevant targets for the early detection and control of these episodes. Presently, there are no uniformly acceptable laboratory markers for LR. Genetic and serum markers in human host may predict susceptibility to reactions as well as progression of nerve damage in leprosy. Therefore, a deeper understanding of the molecular mechanisms involved in LR may provide a rational strategy for early diagnosis and prevention of the catastrophic consequences of LR.
PY - 2013 SP - 739 EP - 49 T2 - Indian journal of dermatology, venereology and leprology TI - New insights in the pathogenesis of type 1 and type 2 lepra reaction. UR - http://www.ijdvl.com/text.asp?2013/79/6/739/120719 VL - 79 SN - 0973-3922 ER -