TY - JOUR
KW - leprosy
KW - Rheumatoid arthritis
KW - Adverse effects
KW - Brazil
AU - Antônio JR
AU - Soubhia RMC
AU - Paschoal VDA
AU - Amarante CF
AU - Travolo ARF
AB - Biological agents are widely used for various immune-mediated diseases, with remarkable effectiveness in the treatment of rheumatoid arthritis (RA), psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. However, attention needs to be drawn to the adverse effects of these therapies and the risk of reactivating underlying granulomatous infectious diseases such as tuberculosis, leprosy, syphilis, leishmaniasis, among others. The objective of this paper is to describe a case of leprosy in a patient with RA using anti-TNF alfa, demonstrating the need for systematic investigation of skin lesions suggestive of leprosy in patients who require rheumatoid arthritis therapeutic treatment, especially in endemic regions like Brazil.
BT - Anais brasileiros de dermatologia
C1 - http://www.ncbi.nlm.nih.gov/pubmed/24346871?dopt=Abstract
CN - ANTONIO 2013
DA - 2013 Nov-Dec
DO - 10.1590/abd1806-4841.20132187
IS - 6 Suppl 1
J2 - An Bras Dermatol
LA - eng
N2 - Biological agents are widely used for various immune-mediated diseases, with remarkable effectiveness in the treatment of rheumatoid arthritis (RA), psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. However, attention needs to be drawn to the adverse effects of these therapies and the risk of reactivating underlying granulomatous infectious diseases such as tuberculosis, leprosy, syphilis, leishmaniasis, among others. The objective of this paper is to describe a case of leprosy in a patient with RA using anti-TNF alfa, demonstrating the need for systematic investigation of skin lesions suggestive of leprosy in patients who require rheumatoid arthritis therapeutic treatment, especially in endemic regions like Brazil.
PY - 2013
SP - 23
EP - 5
T2 - Anais brasileiros de dermatologia
TI - Biological agents: investigation into leprosy and other infectious diseases before indication.
TT - Agentes biológicos: pesquisa de hanseníase e outras doenças infecciosas antes da indicação
UR - http://www.scielo.br/pdf/abd/v88n6s1/0365-0596-abd-88-06-s1-0023.pdf
VL - 88
SN - 1806-4841
ER -