TY - JOUR KW - Peripheral neuropathy KW - Nerve conduction study KW - leprosy KW - Evaluation KW - Brazil AU - Sarno AU - Jardim AU - Illarramendi AU - Hacker AU - Nascimento AU - Vital AU - Balassiano AB -
INTRODUCTION: Leprosy causes nerve injury, which mimics clinical and neurophysiological conditions, rendering it an excellent model of peripheral neuropathy.
METHODS: A retrospective study including 822 nerve conduction studies (NCS) of 509 patients was developed to appraise the electrophysiological pattern of leprosy neuropathy. NCS of motor and sensory nerves performed before, during, and after multidrug therapy (MDT) were analyzed.
RESULTS: During the three periods of MDT, while NCS alterations were similar regarding extension, topography, damage severity, and type of lesion, NCS showed that sensory was more frequent (sural nerve) (92-96%) than motor impairment (70-77%) (ulnar nerve).
CONCLUSION: Once axonal loss has been installed, nerve function is little affected by inflammatory, immune and/or bacterial events since chronic neuropathy has been established, inevitably leading to the well-known leprosy sequelae occurring at any time before and/or after leprosy diagnosis.
BT - Clinical neurology and neurosurgery C1 -http://www.ncbi.nlm.nih.gov/pubmed/25655301?dopt=Abstract
DO - 10.1016/j.clineuro.2015.01.008 J2 - Clin Neurol Neurosurg LA - eng N2 -INTRODUCTION: Leprosy causes nerve injury, which mimics clinical and neurophysiological conditions, rendering it an excellent model of peripheral neuropathy.
METHODS: A retrospective study including 822 nerve conduction studies (NCS) of 509 patients was developed to appraise the electrophysiological pattern of leprosy neuropathy. NCS of motor and sensory nerves performed before, during, and after multidrug therapy (MDT) were analyzed.
RESULTS: During the three periods of MDT, while NCS alterations were similar regarding extension, topography, damage severity, and type of lesion, NCS showed that sensory was more frequent (sural nerve) (92-96%) than motor impairment (70-77%) (ulnar nerve).
CONCLUSION: Once axonal loss has been installed, nerve function is little affected by inflammatory, immune and/or bacterial events since chronic neuropathy has been established, inevitably leading to the well-known leprosy sequelae occurring at any time before and/or after leprosy diagnosis.
PY - 2015 SP - 5 EP - 10 T2 - Clinical neurology and neurosurgery TI - Leprosy neuropathy evaluated by NCS is independent of the patient's infectious state. VL - 131C SN - 1872-6968 ER -