TY - JOUR
KW - Activities of Daily Living
KW - Aged
KW - Brazil
KW - Cross-Sectional Studies
KW - Female
KW - Health Status Indicators
KW - Home Care Services
KW - Humans
KW - leprosy
KW - Linear Models
KW - Male
KW - Mental Health
KW - Perception
KW - Psychiatric Status Rating Scales
KW - Quality of Life
KW - Reproducibility of Results
KW - Socioeconomic Factors
KW - Surveys and Questionnaires
KW - World Health Organization
AU - Chaitanya V S
AU - Jadhav R S
AU - Lavania M
AU - Singh M
AU - Valluri V
AU - Sengupta U
AB - The objective of this study was to investigate the association, if any, between the interleukin-17F (7488T>C) (rs763780) polymorphism and susceptibility to leprosy and to elucidate the relationship between IL-17F genotypes and clinical profile of the disease. DNA was extracted from the peripheral venous blood of leprosy cases (n = 140), which were classified as per WHO classification into paucibacillary (PB) (n = 53) and multibacillary (MB) (n = 87) categories and healthy controls (n = 84) without any signs and symptoms of leprosy. The IL-17F (7488 T/C) polymorphism was genotyped using amplification refractory mutation system - polymerase chain reaction (Allele-specific amplification). In both PB and MB categories of leprosy cases, the homozygous TT genotype frequency was significantly higher than that of the healthy controls (78.70% vs. 29.76%, P < 0.05). The heterozygous TC genotype was higher in the controls than in the leprosy cases (57.14% vs. 17.68%, P < 0.05). TT genotype was more associated with the type 1 reactional states and tuberculoid/borderline tuberculoid groups in leprosy than the TC genotype. This study reveals that the IL-17F (7488T>C) single-nucleotide polymorphism is associated with susceptibility to leprosy and polymorphism confers decrease in risk of contracting leprosy in the north Indian cohort.
BT - International journal of immunogenetics
C1 - http://www.ncbi.nlm.nih.gov/pubmed/24164796?dopt=Abstract
CN - CHAITANYA 2013B
DA - 2014 Apr
DO - 10.1007/s11136-013-0590-7
IS - 2
J2 - Int. J. Immunogenet.
LA - eng
N2 - The objective of this study was to investigate the association, if any, between the interleukin-17F (7488T>C) (rs763780) polymorphism and susceptibility to leprosy and to elucidate the relationship between IL-17F genotypes and clinical profile of the disease. DNA was extracted from the peripheral venous blood of leprosy cases (n = 140), which were classified as per WHO classification into paucibacillary (PB) (n = 53) and multibacillary (MB) (n = 87) categories and healthy controls (n = 84) without any signs and symptoms of leprosy. The IL-17F (7488 T/C) polymorphism was genotyped using amplification refractory mutation system - polymerase chain reaction (Allele-specific amplification). In both PB and MB categories of leprosy cases, the homozygous TT genotype frequency was significantly higher than that of the healthy controls (78.70% vs. 29.76%, P < 0.05). The heterozygous TC genotype was higher in the controls than in the leprosy cases (57.14% vs. 17.68%, P < 0.05). TT genotype was more associated with the type 1 reactional states and tuberculoid/borderline tuberculoid groups in leprosy than the TC genotype. This study reveals that the IL-17F (7488T>C) single-nucleotide polymorphism is associated with susceptibility to leprosy and polymorphism confers decrease in risk of contracting leprosy in the north Indian cohort.
PY - 2014
SP - 131
EP - 7
T2 - International journal of immunogenetics
TI - Interleukin-17F single-nucleotide polymorphism (7488T>C) and its association with susceptibility to leprosy.
VL - 41
SN - 1744-313X
ER -