We recently reported a tuberculosis-negative patient with leprosy, who displayed a giant purified protein derivative (PPD) reaction and had a positive QuantiFERON-TB Gold (QTF; Cellestis, Valencia, CA) test result.1 Concurrently, work was published showing Mycobacterium tuberculosis antigens, early secretory antigenic target (ESAT)-6 kd and culture filtrate protein (CFP)-10 kd, are cross-reactive with M leprae and can lead to false-positive QTF results.2 This supports the notion that QTF assays cannot reliably measure, in patients with leprosy, latent infection with M tuberculosis.
BT - Journal of the American Academy of Dermatology C1 -http://www.ncbi.nlm.nih.gov/pubmed/25437957
DO - 10.1016/j.jaad.2014.05.028 IS - 5 LA - eng N2 -We recently reported a tuberculosis-negative patient with leprosy, who displayed a giant purified protein derivative (PPD) reaction and had a positive QuantiFERON-TB Gold (QTF; Cellestis, Valencia, CA) test result.1 Concurrently, work was published showing Mycobacterium tuberculosis antigens, early secretory antigenic target (ESAT)-6 kd and culture filtrate protein (CFP)-10 kd, are cross-reactive with M leprae and can lead to false-positive QTF results.2 This supports the notion that QTF assays cannot reliably measure, in patients with leprosy, latent infection with M tuberculosis.
PY - 2014 SP - 996 EP - 997 ST - Journal of the American Academy of Dermatology T2 - Journal of the American Academy of Dermatology TI - The utility of QuantiFERON-TB Gold assay in patients with leprosy: A possible measure of anergy VL - 71 SN - 01909622 ER -