Leprosy is a chronic disease caused by Mycobacterium leprae, highly incapacitating, and with systemic involvement in some cases. Renal involvement has been reported in all forms of the disease, and it is more frequent in multibacillary forms. The clinical presentation is variable and is determined by the host immunologic system reaction to the bacilli. During the course of the disease there are the so called reactional states, in which the immune system reacts against the bacilli, exacerbating the clinical manifestations. Different renal lesions have been described in leprosy, including acute and chronic glomerulonephritis, interstitial nephritis, secondary amyloidosis and pyelonephritis. The exact mechanism that leads to glomerulonephritis in leprosy is not completely understood. Leprosy treatment includes rifampicin, dapsone and clofazimine. Prednisone and non-steroidal anti-inflammatory drugs may be used to control acute immunological episodes.
BT - Revista do Instituto de Medicina Tropical de Sao Paulo C1 -http://www.ncbi.nlm.nih.gov/pubmed/25651321?dopt=Abstract
C2 -
C5 -
C7 -
DO - 10.1590/S0036-46652015000100002 IS - 1 J2 - Rev. Inst. Med. Trop. Sao Paulo LA - eng N2 -
Leprosy is a chronic disease caused by Mycobacterium leprae, highly incapacitating, and with systemic involvement in some cases. Renal involvement has been reported in all forms of the disease, and it is more frequent in multibacillary forms. The clinical presentation is variable and is determined by the host immunologic system reaction to the bacilli. During the course of the disease there are the so called reactional states, in which the immune system reacts against the bacilli, exacerbating the clinical manifestations. Different renal lesions have been described in leprosy, including acute and chronic glomerulonephritis, interstitial nephritis, secondary amyloidosis and pyelonephritis. The exact mechanism that leads to glomerulonephritis in leprosy is not completely understood. Leprosy treatment includes rifampicin, dapsone and clofazimine. Prednisone and non-steroidal anti-inflammatory drugs may be used to control acute immunological episodes.
PY - 2015 SP - 15 EP - 20 T2 - Revista do Instituto de Medicina Tropical de Sao Paulo TI - Leprosy Nephropathy : A Review of Clinical and Histopathological Features TT - Nefropatia da hanseníase: revisão dos aspectos clínicos e histopatológicos UR - http://www.scielo.br/pdf/rimtsp/v57n1/0036-4665-rimtsp-57-01-15.pdf VL - 57 SN - 1678-9946 ER -