TY - JOUR KW - Therapeutics KW - Prevention & control KW - Parasitology KW - Parasitic Diseases KW - Parasites KW - Neglected Diseases KW - Helminths KW - Epilepsy KW - diagnosis KW - Central Nervous System AU - Carpio A AU - Romo M AU - Parkhouse M AU - Short B AU - Dua T AB -

Parasitic diseases of the central nervous system are associated with high mortality and morbidity, especially in resource-limited settings. The burden of these diseases is amplified as survivors are often left with neurologic sequelae affecting mobility, sensory organs, and cognitive functions, as well as seizures/epilepsy. These diseases inflict suffering by causing lifelong disabilities, reducing economic productivity, and causing social stigma. The complexity of parasitic life cycles and geographic specificities, as well as overlapping clinical manifestations in the host reflecting the diverse pathogenesis of parasites, can present diagnostic challenges. We herein provide an overview of these parasitic diseases and summarize clinical aspects, diagnosis, therapeutic strategies and recent milestones, and aspects related to prevention and control.

BT - Expert review of neurotherapeutics C1 -

http://www.ncbi.nlm.nih.gov/pubmed/26894629?dopt=Abstract

DO - 10.1586/14737175.2016.1155454 IS - 3 J2 - Expert Rev Neurother LA - eng N2 -

Parasitic diseases of the central nervous system are associated with high mortality and morbidity, especially in resource-limited settings. The burden of these diseases is amplified as survivors are often left with neurologic sequelae affecting mobility, sensory organs, and cognitive functions, as well as seizures/epilepsy. These diseases inflict suffering by causing lifelong disabilities, reducing economic productivity, and causing social stigma. The complexity of parasitic life cycles and geographic specificities, as well as overlapping clinical manifestations in the host reflecting the diverse pathogenesis of parasites, can present diagnostic challenges. We herein provide an overview of these parasitic diseases and summarize clinical aspects, diagnosis, therapeutic strategies and recent milestones, and aspects related to prevention and control.

PY - 2016 T2 - Expert review of neurotherapeutics TI - Parasitic diseases of the central nervous system: lessons for clinicians and policy makers. VL - 16 SN - 1744-8360 ER -