TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Case-Control Studies
KW - Female
KW - Gastric Mucosa
KW - Gastritis, Atrophic
KW - Helicobacter Infections
KW - Helicobacter pylori
KW - Humans
KW - leprosy
KW - Male
KW - Middle Aged
AU - Misra V
AU - Misra S P
AU - Hatwal D
AU - Dwivedi M
AU - Singh K G
AU - Bajaj A K
AB - <p>Two antral biopsies each from 104 patients of leprosy and 100 controls were studied to find out the prevalence of H. pylori and associated histopathological changes. Sections were stained with hematoxylene and eosin, AB/PAS (Ph 2.5) and Loeffler's methylene blue stains. Infection by H. pylori, inflammation and atrophy were found to be significantly more in leprosy patients as compared to controls (p < 0.01, < 0.005 and < 0.02 respectively). On comparing the histopathological changes in various subgroups of leprosy, H. pylori, inflammation and activity showed a statistically decreasing trend from tuberculoid to lepromatous subgroups (p < 0.05, < 0.001, < 0.01 respectively). Atrophy showed a significant increasing trend from tuberculoid to lepromatous group (< 0.001), it is concluded that despite a low prevalence of H. pylori and associated gastritis in patients with lepromatous leprosy, gastric epithelial damage is more marked due to altered immune response.</p>
BT - Indian journal of pathology & microbiology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/12024911?dopt=Abstract
DA - 2001 Jul
IS - 3
J2 - Indian J Pathol Microbiol
LA - eng
N2 - <p>Two antral biopsies each from 104 patients of leprosy and 100 controls were studied to find out the prevalence of H. pylori and associated histopathological changes. Sections were stained with hematoxylene and eosin, AB/PAS (Ph 2.5) and Loeffler's methylene blue stains. Infection by H. pylori, inflammation and atrophy were found to be significantly more in leprosy patients as compared to controls (p < 0.01, < 0.005 and < 0.02 respectively). On comparing the histopathological changes in various subgroups of leprosy, H. pylori, inflammation and activity showed a statistically decreasing trend from tuberculoid to lepromatous subgroups (p < 0.05, < 0.001, < 0.01 respectively). Atrophy showed a significant increasing trend from tuberculoid to lepromatous group (< 0.001), it is concluded that despite a low prevalence of H. pylori and associated gastritis in patients with lepromatous leprosy, gastric epithelial damage is more marked due to altered immune response.</p>
PY - 2001
SP - 271
EP - 5
T2 - Indian journal of pathology & microbiology
TI - Helicobacter pylori and associated histopathological changes in gastric biopsies of patients with leprosy.
VL - 44
SN - 0377-4929
ER -