TY - JOUR
KW - Prednisolone
KW - Methotrexate
KW - leprosy
KW - Chronic neuritis
AU - Hossain D
AB - <p><strong>INTRODUCTION: </strong>Recommended fixed duration prednisolone regimen was not found effective in the treatment of chronic neuritis. Alternate effective treatment was being sought to reduce the deformity in the field of leprosy.</p>

<p><strong>OBJECTIVE: </strong>We wished to see whether a prolonged course of prednisolone and methotrexate could be of any help for them.</p>

<p><strong>METHODOLOGY: </strong>In 2012-2014, an open pilot clinical study was undertaken where three chronic neuritic patients were treated with lower doses prednisolone and methotrexate for 12 months and a follow up period was delivered for 12 months. The study was undertaken in one of the outdoor clinics of the university.</p>

<p><strong>RESULTS: </strong>Complete and permanent remission of neuritis was achieved with appreciable functional recovery. Few mild self-limiting side-effects from prednisolone were observed and there was no side-effects from methotrexate.</p>

<p><strong>CONCLUSION: </strong>Prolonged course of prednisolone and methotrexate was found safe and effective in treating chronic neuritis.</p>

BT - Leprosy review
C1 - <p>http://www.ncbi.nlm.nih.gov/pubmed/27255067?dopt=Abstract</p>

IS - 1
J2 - Lepr Rev
LA - eng
N2 - <p><strong>INTRODUCTION: </strong>Recommended fixed duration prednisolone regimen was not found effective in the treatment of chronic neuritis. Alternate effective treatment was being sought to reduce the deformity in the field of leprosy.</p>

<p><strong>OBJECTIVE: </strong>We wished to see whether a prolonged course of prednisolone and methotrexate could be of any help for them.</p>

<p><strong>METHODOLOGY: </strong>In 2012-2014, an open pilot clinical study was undertaken where three chronic neuritic patients were treated with lower doses prednisolone and methotrexate for 12 months and a follow up period was delivered for 12 months. The study was undertaken in one of the outdoor clinics of the university.</p>

<p><strong>RESULTS: </strong>Complete and permanent remission of neuritis was achieved with appreciable functional recovery. Few mild self-limiting side-effects from prednisolone were observed and there was no side-effects from methotrexate.</p>

<p><strong>CONCLUSION: </strong>Prolonged course of prednisolone and methotrexate was found safe and effective in treating chronic neuritis.</p>

PY - 2016
SP - 118
EP - 21
T2 - Leprosy review
TI - Management of chronic neuritis with a combination regimen of lower doses prednisolone and methotrexate: a brief report.
UR - https://leprosyreview.org/article/87/1/11-8121
VL - 87
SN - 0305-7518
ER -