TY - JOUR KW - Trachoma KW - Odds Ratio KW - Logistic Models KW - Infant KW - Humans KW - Ethiopia KW - Communicable Disease Control KW - Child, Preschool KW - Azithromycin KW - Anti-Bacterial Agents AU - Chidambaram J AU - Melese M AU - Alemayehu W AU - Yi E AU - Prabriputaloong T AU - Lee DC AU - Cevallos V AU - Zhou Z AU - Whitcher J AU - Gaynor B AU - Lietman TM AB -

Azithromycin is highly effective against trachoma, but the practical difficulties of community-wide distribution often leave many individuals untreated. We demonstrate, after mass azithromycin treatment of a population in Ethiopia, an indirect protective effect that occurred among untreated children who resided in villages in which most individuals had been treated. Similarities with the indirect protection within a treated community (i.e., "herd protection") that has been observed in vaccination programs are discussed.

BT - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America C1 -

http://www.ncbi.nlm.nih.gov/pubmed/15494901?dopt=Abstract

DO - 10.1086/424747 IS - 9 J2 - Clin. Infect. Dis. LA - eng N2 -

Azithromycin is highly effective against trachoma, but the practical difficulties of community-wide distribution often leave many individuals untreated. We demonstrate, after mass azithromycin treatment of a population in Ethiopia, an indirect protective effect that occurred among untreated children who resided in villages in which most individuals had been treated. Similarities with the indirect protection within a treated community (i.e., "herd protection") that has been observed in vaccination programs are discussed.

PY - 2004 SP - e95 EP - 7 T2 - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America TI - Mass antibiotic treatment and community protection in trachoma control programs. UR - http://cid.oxfordjournals.org/content/39/9/e95.full.pdf+html VL - 39 SN - 1537-6591 ER -