Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. This suggests that NTZ could be considered for leprosy treatment.
BT - PloS one C1 -http://www.ncbi.nlm.nih.gov/pubmed/28850614?dopt=Abstract
DO - 10.1371/journal.pone.0184107 IS - 8 J2 - PLoS ONE LA - eng N2 -Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. This suggests that NTZ could be considered for leprosy treatment.
PY - 2017 EP - e0184107 T2 - PloS one TI - Nitazoxanide is active against Mycobacterium leprae. UR - http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184107&type=printable VL - 12 SN - 1932-6203 ER -