TY - JOUR KW - Macrophages KW - Nerve cells KW - Demyelination KW - Phenolic glycolipids KW - leprosy AU - Dunlap MD AU - Khader S AB -

How Mycobacterium leprae infection causes demyelination to mediate leprosy pathogenesis has been a long-standing question. In a recent Cell paper, Madigan et al. (2017) use a zebrafish model of M. leprae infection to show that infected macrophages patrol axons to trigger mitochondrial damage and induce demyelination of nerve cells.

BT - Cell host & microbe C1 -

http://www.ncbi.nlm.nih.gov/pubmed/28910627?dopt=Abstract

DO - 10.1016/j.chom.2017.08.016 IS - 3 J2 - Cell Host Microbe LA - eng N2 -

How Mycobacterium leprae infection causes demyelination to mediate leprosy pathogenesis has been a long-standing question. In a recent Cell paper, Madigan et al. (2017) use a zebrafish model of M. leprae infection to show that infected macrophages patrol axons to trigger mitochondrial damage and induce demyelination of nerve cells.

PY - 2017 SP - 249 EP - 251 T2 - Cell host & microbe TI - Dancing with the Stars: Phenolic Glycolipids Partners with Macrophages. VL - 22 SN - 1934-6069 ER -