TY - ECHAP
KW - Neglected tropical diseases (NTDs)
KW - Leishmaniasis
KW - Chagas disease
KW - Trypanosomiasis
KW - Treatment
KW - Benznidazole
KW - Chemotherapy
KW - Clinical trials
KW - drug development
KW - Drug repurposing
KW - Drug Resistance
KW - Glucantime
KW - Leishmania spp.
KW - Medicinal chemistry
KW - New pharmaceuticals
KW - New treatment schemes
KW - Pentavalent antimonials
KW - Pentostam
KW - Side effects
KW - Trypanosoma cruzi
KW - Trypanosomatids
AU - Accioly Brelaz de Castro MC
AU - Silva AC
AU - Ramos dos Santos TA
AU - Costa Oliveira CN
AU - Silva de Morais RC
AU - Paiva-Cavalcanti M
AU - Alves Pereira VR
AB - <p>Leishmaniasis and trypanosomiasis are challenges among neglected tropical diseases. They usually affect marginal and poor populations and have the potential of becoming lethal. Current treatment for both diseases is based on chemotherapy, with the drug of choice being pentavalent antimonials for leishmaniasis, while for Chagas disease the two nitro-heterocyclic drugs, Benznidazole and Nifurtimox are recommended. The limited number, low efficacy, and side effects of conventional anti-Leishmania and anti-Trypanosomal drugs and the resistance developed by parasites are the major factors responsible for the growth in mortality rates. Currently there is an urgent need to develop effective, safe, cost-effective drugs, and new treatment schemes, as well as vaccines. As a result, international health organizations, universities, foundations, and pharmaceutical corporations are working together to support analysis and development of new strategies for controlling these diseases.</p>

BT - Tropical Diseases: An Overview of Major Diseases Occurring in the Americas
DO - 10.2174/9781681085876117010110.2174/9781681085876117010007
LA - eng
N2 - <p>Leishmaniasis and trypanosomiasis are challenges among neglected tropical diseases. They usually affect marginal and poor populations and have the potential of becoming lethal. Current treatment for both diseases is based on chemotherapy, with the drug of choice being pentavalent antimonials for leishmaniasis, while for Chagas disease the two nitro-heterocyclic drugs, Benznidazole and Nifurtimox are recommended. The limited number, low efficacy, and side effects of conventional anti-Leishmania and anti-Trypanosomal drugs and the resistance developed by parasites are the major factors responsible for the growth in mortality rates. Currently there is an urgent need to develop effective, safe, cost-effective drugs, and new treatment schemes, as well as vaccines. As a result, international health organizations, universities, foundations, and pharmaceutical corporations are working together to support analysis and development of new strategies for controlling these diseases.</p>

PB - BENTHAM SCIENCE PUBLISHERS
PY - 2017
SE - 4
EP - 15
T2 - Tropical Diseases: An Overview of Major Diseases Occurring in the Americas
TI - Leishmaniasis and Chagas disease treatment.
UR - https://tinyurl.com/y8oz9bcl
ER -