TY - JOUR
KW - Dapsone
KW - HLA-B*13:01
KW - leprosy
KW - Malaysia
KW - Severe cutaneous adverse reaction
AU - Ramalingam R
AU - Too CL
AU - Tang MM
AB - <p>Dapsone is part of the multi-drug therapy used in the treatment of leprosy. It can cause life-threatening hypersensitivity syndromes resulting in significant morbidity and mortality, especially among susceptible individuals such as those who are carriers of HLA-B*13:01 allele. Avoidance of dapsone in these susceptible individuals reduces the risk of dapsone-related adverse events. Herein, we report four indigenous patients with leprosy who developed dapsone hypersensitivity syndrome.</p>

BT - Malaysian journal of dermatology
LA - eng
N2 - <p>Dapsone is part of the multi-drug therapy used in the treatment of leprosy. It can cause life-threatening hypersensitivity syndromes resulting in significant morbidity and mortality, especially among susceptible individuals such as those who are carriers of HLA-B*13:01 allele. Avoidance of dapsone in these susceptible individuals reduces the risk of dapsone-related adverse events. Herein, we report four indigenous patients with leprosy who developed dapsone hypersensitivity syndrome.</p>

PY - 2018
SP - 73
EP - 79
T2 - Malaysian journal of dermatology
TI - Dapsone Hypersensitivity Syndrome and Dapsone-induced Liver Injury in Four Malaysian Indigenous Individuals with Leprosy
UR - http://www.dermatology.org.my/pdf/Malaysian_Journal_of_Dermatology_2018_05Jul18.pdf#page=75
VL - 40
ER -