TY - JOUR
KW - leprosy
KW - Mid borderline leprosy (BB)
KW - Blaschko
KW - Blaschko linear pattern
AU - Chetan R
AU - Shailesh M
AB - <p><strong>INTRODUCTION: </strong>Leprosy is a chronic granulomatous disease caused by M. leprae. It is a great imitator as it can manifest in different unusual and atypical ways. Mid borderline leprosy (BB) is an unstable form representing the immunologic midpoint in the clinical spectrum.</p>

<p><strong>CASE REPORT: </strong>Here, we report a case of BB leprosy having classical inverted saucer-shaped lesions elsewhere on the body with a linear psoriasiform lesion over the left forearm following the lines of Blaschko. Biopsy from this lesion revealed granulomas consisting of equal admixture of epithelioid cells and macrophages without multinucleate giant cells suggesting mid borderline leprosy.</p>

<p><strong>CONCLUSION: </strong>Occurrence of lesions in a Blaschko linear pattern supports the role of genetic susceptibility to leprosy. The genetically vulnerable cells along the lines of Blaschko were infected while the surrounding cells remained unaffected. This explains the concept of locus minoris resistentiae due to cutaneous mosaicism.</p>

BT - International journal of dermatology
C1 - <p>http://www.ncbi.nlm.nih.gov/pubmed/30345504?dopt=Abstract</p>

DO - 10.1111/ijd.14274
J2 - Int. J. Dermatol.
LA - eng
N2 - <p><strong>INTRODUCTION: </strong>Leprosy is a chronic granulomatous disease caused by M. leprae. It is a great imitator as it can manifest in different unusual and atypical ways. Mid borderline leprosy (BB) is an unstable form representing the immunologic midpoint in the clinical spectrum.</p>

<p><strong>CASE REPORT: </strong>Here, we report a case of BB leprosy having classical inverted saucer-shaped lesions elsewhere on the body with a linear psoriasiform lesion over the left forearm following the lines of Blaschko. Biopsy from this lesion revealed granulomas consisting of equal admixture of epithelioid cells and macrophages without multinucleate giant cells suggesting mid borderline leprosy.</p>

<p><strong>CONCLUSION: </strong>Occurrence of lesions in a Blaschko linear pattern supports the role of genetic susceptibility to leprosy. The genetically vulnerable cells along the lines of Blaschko were infected while the surrounding cells remained unaffected. This explains the concept of locus minoris resistentiae due to cutaneous mosaicism.</p>

PY - 2018
T2 - International journal of dermatology
TI - Mid borderline leprosy in type Bα Blaschko linear pattern: a rare phenomenon.
SN - 1365-4632
ER -