TY - JOUR
KW - Algorithms
KW - Cluster Analysis
KW - Colony Count, Microbial
KW - Cytokines
KW - Gene Expression Profiling
KW - Gene Expression Regulation
KW - Genes, Immunoglobulin
KW - Humans
KW - Immunity, Cellular
KW - Immunity, Innate
KW - Leprosy, lepromatous
KW - Leprosy, Tuberculoid
KW - Macrophages, Alveolar
KW - Membrane Glycoproteins
KW - Mycobacterium tuberculosis
KW - Oligonucleotide Array Sequence Analysis
KW - polymerase chain reaction
KW - Principal Component Analysis
KW - Receptors, Cell Surface
KW - Receptors, Immunologic
KW - Toll-Like Receptors
KW - Up-Regulation
AU - Bleharski J
AU - Li H
AU - Meinken C
AU - Graeber T
AU - Ochoa M
AU - Yamamura M
AU - Burdick A
AU - Sarno E
AU - Wagner M
AU - Röllinghoff M
AU - Rea T
AU - Colonna M
AU - Stenger S
AU - Bloom B
AU - Eisenberg D
AU - Modlin RL
AB - <p>Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.</p>
BT - Science (New York, N.Y.)
C1 - http://www.ncbi.nlm.nih.gov/pubmed/12970564?dopt=Abstract
CN - BLEHARSKI2003
DA - 2003 Sep 12
DO - 10.1126/science.1087785
IS - 5639
J2 - Science
LA - eng
N2 - <p>Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.</p>
PY - 2003
SP - 1527
EP - 30
T2 - Science (New York, N.Y.)
TI - Use of genetic profiling in leprosy to discriminate clinical forms of the disease.
VL - 301
SN - 1095-9203
ER -