BACKGROUND: Dermatologic conditions are often an early clue to human immunodeficiency virus (HIV) infection. As the disease progresses and the host immunity fails, patients may develop a number of skin conditions. At this point, they have a dominant T helper 2 immunologic response. After the initiation of antiretroviral therapy, the T helper 1 response is restored, and some skin problems, paradoxically, make their appearance then.
CONCLUSION: Herpes zoster, mucocutaneous herpes, eosinophilic folliculitis, and mycobacterial infections have been known to occur at this stage. This may be because immune restoration of a host's immunity causes recognition of silent or latent infection and results in development of the condition. We report five cases that were seen at our center during a 2-year period.
BT - Journal of cutaneous medicine and surgery C1 - http://www.ncbi.nlm.nih.gov/pubmed/18544296?dopt=Abstract DA - 2008 May-Jun DO - 10.2310/7750.2008.07017 IS - 3 J2 - J Cutan Med Surg LA - eng N2 -BACKGROUND: Dermatologic conditions are often an early clue to human immunodeficiency virus (HIV) infection. As the disease progresses and the host immunity fails, patients may develop a number of skin conditions. At this point, they have a dominant T helper 2 immunologic response. After the initiation of antiretroviral therapy, the T helper 1 response is restored, and some skin problems, paradoxically, make their appearance then.
CONCLUSION: Herpes zoster, mucocutaneous herpes, eosinophilic folliculitis, and mycobacterial infections have been known to occur at this stage. This may be because immune restoration of a host's immunity causes recognition of silent or latent infection and results in development of the condition. We report five cases that were seen at our center during a 2-year period.
PY - 2008 SP - 126 EP - 32 T2 - Journal of cutaneous medicine and surgery TI - Dermatologic immune restoration syndrome: report of five cases from a tertiary care center in north India. VL - 12 SN - 1203-4754 ER -