TY - JOUR
KW - Adult
KW - Analysis of Variance
KW - Antibodies
KW - Antigens, Bacterial
KW - Antitubercular Agents
KW - Cardiolipins
KW - Cerebrosides
KW - Female
KW - Follow-Up Studies
KW - Glycolipids
KW - Humans
KW - Leprostatic Agents
KW - Leprosy, lepromatous
KW - Lipids
KW - Male
KW - Mycobacterium
KW - Mycobacterium leprae
KW - Mycobacterium tuberculosis
KW - Statistics, Nonparametric
KW - Tuberculosis, Pulmonary
KW - Virulence Factors
AU - Rojas-Espinosa O
AU - Arenas R
AU - Arce-Parades P
AU - Miranda-Contreras G
AB - <p>In this study we looked for the presence of antibodies to cardiolipin, cerebrosides, and whole lipids extracted from M. leprae, M. tuberculosis and M. habana, in the serum of patients with clinically cured lepromatous leprosy (sixteen) or tuberculosis (sixteen), 8 to 12 months after arresting the corresponding multi-drug therapy (MDT). Compared to healthy controls (sixteen), both leprosy and tuberculosis ex-patients had still significant levels of antibodies to the three mycobacterial lipids but no detectable levels of antibodies to cardiolipin or cerebroside lipids. Although leprosy and tuberculosis sera recognized the homologous mycobacterial lipids in a preferential fashion, all of them, on the average, reacted more strongly with the lipids of M. habana. This observation backs up, in a certain way, the proposition of using M. habana as a prospective vaccine for leprosy and tuberculosis.</p>
BT - Acta leprologica
C1 - http://www.ncbi.nlm.nih.gov/pubmed/15040701?dopt=Abstract
DA - 2003
IS - 3
J2 - Acta Leprol
LA - eng
N2 - <p>In this study we looked for the presence of antibodies to cardiolipin, cerebrosides, and whole lipids extracted from M. leprae, M. tuberculosis and M. habana, in the serum of patients with clinically cured lepromatous leprosy (sixteen) or tuberculosis (sixteen), 8 to 12 months after arresting the corresponding multi-drug therapy (MDT). Compared to healthy controls (sixteen), both leprosy and tuberculosis ex-patients had still significant levels of antibodies to the three mycobacterial lipids but no detectable levels of antibodies to cardiolipin or cerebroside lipids. Although leprosy and tuberculosis sera recognized the homologous mycobacterial lipids in a preferential fashion, all of them, on the average, reacted more strongly with the lipids of M. habana. This observation backs up, in a certain way, the proposition of using M. habana as a prospective vaccine for leprosy and tuberculosis.</p>
PY - 2003
SP - 112
EP - 6
T2 - Acta leprologica
TI - Antibodies to diverse lipids in the serum of patients with clinically cured leprosy and tuberculosis.
VL - 12
SN - 0001-5938
ER -