TY - JOUR
KW - Case-Control Studies
KW - Cohort Studies
KW - Humans
KW - Incidence
KW - Indonesia
KW - Leprostatic Agents
KW - leprosy
KW - Rifampin
AU - Bakker MI
AU - Hatta M
AU - Kwenang A
AU - Van Benthem BH B
AU - Beers SM
AU - Klatser P
AU - Oskam L
AB - <p>An intervention study was implemented on five Indonesian islands highly endemic for leprosy to determine whether rifampicin can be used as chemoprophylaxis to prevent leprosy. The population was actively screened before the intervention and subsequently once a year for three years. In the control group, no chemoprophylaxis was given. In the contact group, chemoprophylaxis was only given to contacts of leprosy patients and in the blanket group to all eligible persons. The cohort consisted of 3,965 persons. The yearly incidence rate in the control group was 39/10,000; the cumulative incidence after three years was significantly lower in the blanket group (P = 0.031). No difference was found between the contact and the control groups (P = 0.93). Whether this apparent reduced leprosy incidence in the first three years in the blanket group is due to a delayed development of leprosy or a complete clearance of infection needs to be determined.</p>
BT - The American journal of tropical medicine and hygiene
C1 - http://www.ncbi.nlm.nih.gov/pubmed/15827283?dopt=Abstract
CN - BAKKER 2005
DA - 2005 Apr
IS - 4
J2 - Am. J. Trop. Med. Hyg.
LA - eng
N2 - <p>An intervention study was implemented on five Indonesian islands highly endemic for leprosy to determine whether rifampicin can be used as chemoprophylaxis to prevent leprosy. The population was actively screened before the intervention and subsequently once a year for three years. In the control group, no chemoprophylaxis was given. In the contact group, chemoprophylaxis was only given to contacts of leprosy patients and in the blanket group to all eligible persons. The cohort consisted of 3,965 persons. The yearly incidence rate in the control group was 39/10,000; the cumulative incidence after three years was significantly lower in the blanket group (P = 0.031). No difference was found between the contact and the control groups (P = 0.93). Whether this apparent reduced leprosy incidence in the first three years in the blanket group is due to a delayed development of leprosy or a complete clearance of infection needs to be determined.</p>
PY - 2005
SP - 443
EP - 8
T2 - The American journal of tropical medicine and hygiene
TI - Prevention of leprosy using rifampicin as chemoprophylaxis.
UR - https://kit2018.wpenginepowered.com/wp-content/uploads/2020/09/prevention.pdf
VL - 72
SN - 0002-9637
ER -