TY - JOUR
KW - Brazil
KW - Case-Control Studies
KW - DNA Mutational Analysis
KW - Female
KW - Genetic Markers
KW - Humans
KW - Immunity, Innate
KW - Indians, South American
KW - Interleukin-10
KW - leprosy
KW - Male
KW - polymerase chain reaction
KW - Polymorphism, Single Nucleotide
KW - Promoter Regions, Genetic
KW - Quantitative Trait Loci
AU - Malhotra D
AU - Darvishi K
AU - Sood S
AU - Sharma S
AU - Grover C
AU - Relhan V
AU - Reddy B S N
AU - Bamezai R N K
AB - <p>The minor haplotype -3575A/-2849G/-2763C in IL-10 promoter has been defined as a marker of disease resistance to leprosy and its severity in Brazilian population. Our investigation of six single-nucleotide polymorphisms (SNPs) in IL-10 promoter in 282 Indian leprosy patients and 266 healthy controls by direct PCR sequencing, however, showed that the extended haplotype: -3575T/-2849G/-2763C/-1082A/-819C/-592C was associated with resistance to leprosy per se and to the development of severe form of leprosy, using either a binomial (controls vs cases, P=0.01, OR=0.58, CI=0.37-0.89) or ordinal (controls vs paucibacillary vs multibacillary, P=0.004) model. Whereas, IL-10 haplotype -3575T/-2849G/-2763C/-1082A/-819T/-592A was associated with the risk of development of severe form of leprosy (P=0.0002) in contrast to the minor risk haplotype -3575T/-2849A/-2763C in the Brazilian population. The role of IL-10 promoter SNPs in Brazilian and Indian population strongly suggests the involvement of IL-10 locus in the outcome of leprosy.</p>
BT - Human genetics
C1 - http://www.ncbi.nlm.nih.gov/pubmed/16163478?dopt=Abstract
DA - 2005 Nov
DO - 10.1007/s00439-005-0042-8
IS - 2
J2 - Hum. Genet.
LA - eng
N2 - <p>The minor haplotype -3575A/-2849G/-2763C in IL-10 promoter has been defined as a marker of disease resistance to leprosy and its severity in Brazilian population. Our investigation of six single-nucleotide polymorphisms (SNPs) in IL-10 promoter in 282 Indian leprosy patients and 266 healthy controls by direct PCR sequencing, however, showed that the extended haplotype: -3575T/-2849G/-2763C/-1082A/-819C/-592C was associated with resistance to leprosy per se and to the development of severe form of leprosy, using either a binomial (controls vs cases, P=0.01, OR=0.58, CI=0.37-0.89) or ordinal (controls vs paucibacillary vs multibacillary, P=0.004) model. Whereas, IL-10 haplotype -3575T/-2849G/-2763C/-1082A/-819T/-592A was associated with the risk of development of severe form of leprosy (P=0.0002) in contrast to the minor risk haplotype -3575T/-2849A/-2763C in the Brazilian population. The role of IL-10 promoter SNPs in Brazilian and Indian population strongly suggests the involvement of IL-10 locus in the outcome of leprosy.</p>
PY - 2005
SP - 295
EP - 300
T2 - Human genetics
TI - IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy.
VL - 118
SN - 0340-6717
ER -